{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Prof.GangLi, faculty of health and science, university of macau"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA399160"],"scientific_name":["Homo sapiens"],"long_description":["Lysine27Methionine mutations (K27M) in the histone H3 (H3.3 and H3.1) are highly prevalent in pediatric high-grade gliomas (HGG). This study found H3.3K27M caused the upregulation of multiple cancer/testis (CT) antigens, include IL13RA2 and VCX family proteins. Overexpression of VCX3A/B stimulates the expression of genes involved in immune response. Overall design: Total RNA was extracted from Res259 cells stably expressing H3.3K27M, pCMV6-Entry (empty vector), different forms of GFP-VCX3A/B, or GFP (as control), and subjected to an Illumina HT12.2 Bead CHIP array analysis."],"tag":["xref:PubMed:29453317"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Homo sapiens","description":"Histone H3.3K27M mutation activates multiple cancer/testis antigens","dates":{"last_updated":"2025-09-24","first_public":"2018-08-02"},"accession":"PRJNA399160","cross_references":{"GEO":["GSE102886"],"taxon":["9606"],"PubMed":["29453317"]}}