ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/009/SRR6262169/SRR6262169_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/000/SRR6262170/SRR6262170_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/008/SRR6262168/SRR6262168_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/001/SRR6262171/SRR6262171_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/008/SRR6262168/SRR6262168_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/001/SRR6262171/SRR6262171_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/000/SRR6262170/SRR6262170_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR626/009/SRR6262169/SRR6262169_1.fastq.gzprimaryOK200GenomicsThe Ohio State Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA416813Homo sapiensFhit is a tumor suppressor/genomic protective protein that is lost in more than 50% of cancers but the mechanism by which it works is unknown. Unlike most tumor suppressors Fhit is a cytoplasmic protein with no known interacting partners. A previous study found that Fhit regulates the translation of thymidine kinase 1 (TK1) mRNA into protein, with greater TK1 translation in Fhit-positive versus Fhit-negative cells. Increased TK1 translation was dependent on the ability of Fhit to degrade small RNA fragments termed nucleoside 5’,5’-triphosphates. The goal of this study was to identify mRNAs whose translation is regulated by Fhit, and use this information to identify the proteins that are responsible for its tumor suppressor/genome protective effects.ENAHuman, strain, H1299, human being, Man (Taxonomy), Homo sapiens, CRL-5803., Modern Man, Modern, cultivar, NCI-H1299, man, Man, ecotype, humanpreventive measures, Fra14A2, Controlling, FRA3B, preventive therapy, Polyribosome, AW045638, reference sample, control, determination, prophylaxis, AP3Aase, polyribosome, chemical analysis., assay, prevention and control, Polysomes, Polysome, Controlled, preventionfalseHomo sapiens cultivar:NCI-H1299Identification of mRNAs under translational control by Fhit using polysome gradient analysis2025-09-242017-11-10PRJNA4168139606