{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Laboratorio 12, Centro de Investigación del Cáncer IBMCC-CIC"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA422888"],"scientific_name":["Homo sapiens"],"long_description":["AIM: To investigate whether chromosomal instability (CIN) is associated with tumor phenotypes and/or with global genomic status based on MSI (microsatellite instability) and CIMP (CpG island methylator phenotype) in early onset colorectal cancer (EOCRC). METHODS: Taking as a starting point our previous work in which tumors from 60 EOCRC cases (≤45 years at the time of diagnosis) were analyzed by array comparative genomic hybridization (aCGH), in the present study we performed an unsupervised hierarchical clustering analysis of those aCGH data in order to unveil possible associations between the CIN profile and the clinical features of the tumors. In addition, we evaluated the MSI and the CIMP statuses of the samples with the aim of investigating a possible relationship between copy number alterations (CNAs) and the MSI/CIMP condition in EOCRC. RESULTS: Based on the similarity of the CNAs detected, the unsupervised analysis stratified samples into two main clusters (A, B) and four secondary clusters (A1, A2, B3, B4). The different subgroups showed a certain correspondence with the molecular classification of colorectal cancer (CRC), which enabled us to outline an algorithm to categorize tumors according to their CIMP status. Interestingly, each subcluster showed some distinctive clinicopathological features. But more interestingly, the CIN of each subcluster mainly affected articular chromosomes, allowing us to define chromosomal regions more specifically affected depending on the CIMP/MSI status of the samples. CONCLUSIONS: Our findings may provide a basis for a new form of classifying EOCRC according to the genomic status of the tumors. Overall design: A total of 88 individuals diagnosed with CRC at an age of 45 years or younger (range: 16–45 years) were collected at the 12 de Octubre University Hospital in Madrid. Family history of cancer (including at least three generations) and clinicopathological information was obtained for each patient, with a follow-up of at least 60months from surgery. Six patients were excluded because familial adenomatous polyposis was diagnosed Material for array comparative genomic hybridization (aCGH) analysis could be obtained from 60 of the remaining 82 patients."],"repository":["ENA"],"description_synonyms":["Colorectal Neoplasm, Carcinoma, Comparative Genome, Array-Based Comparative Genomic Hybridization, Colorectal Cancer, determination, Genomic Hybridizations, Hybridization, taxonomy, Comparative, Neoplasms, Phenotypes., Systematics, Comparative Genome Hybridization, Tumor, Hybridizations, autosomal dominant, Fs(3)Sz11, Classifications, Colorectal, colorectal cancer, Taxonomies, hierarchies, hierarchy, Array Comparative Genomic Hybridization, systematics, chemical analysis, Neoplasm, DmF2, CRC, Colorectal Cancers, Comparative Genome Hybridizations, Fs(3)Hor, lod, Colorectal Tumors, Carcinomas, large bowel cancer, DmelCG2684, Taxonomy, Array Based Comparative Genomic Hybridization, susceptibility to, Colorectal Carcinoma, Age of onset, Colorectal Carcinomas, Cancers, chromosomal comparative genomic hybridization, NTef2, Age symptoms begin, Colorectal Tumor, Lds, cancer of large bowel, early, large intestine cancer, cancer of the large intestine, Genome Hybridization, Comparative Genomic, colon cancer, Genomic Hybridization, Horka, comparative genomic hybridization, Genome Hybridizations, Comparative Genomic Hybridizations, CG2684, Fs(3)Horka, cancer of the large bowel, microarray, assay, cancer of large intestine, somatic mutation, colorectal (colon or rectal) cancer, Tumors, Cancer"],"name_synonyms":["Colorectal Neoplasm, Carcinoma, Comparative Genome, Array-Based Comparative Genomic Hybridization, Colorectal Cancer, determination, Genomic Hybridizations, Hybridization, taxonomy, Comparative, Neoplasms, Phenotypes., Systematics, Comparative Genome Hybridization, Tumor, Hybridizations, autosomal dominant, Fs(3)Sz11, Classifications, Colorectal, colorectal cancer, Taxonomies, hierarchies, hierarchy, Array Comparative Genomic Hybridization, systematics, chemical analysis, Neoplasm, DmF2, CRC, Colorectal Cancers, Comparative Genome Hybridizations, Fs(3)Hor, lod, Colorectal Tumors, Carcinomas, large bowel cancer, DmelCG2684, Taxonomy, Array Based Comparative Genomic Hybridization, susceptibility to, Colorectal Carcinoma, Age of onset, Colorectal Carcinomas, Cancers, chromosomal comparative genomic hybridization, NTef2, Age symptoms begin, Colorectal Tumor, Lds, cancer of large bowel, early, large intestine cancer, cancer of the large intestine, Genome Hybridization, Comparative Genomic, colon cancer, Genomic Hybridization, Horka, comparative genomic hybridization, Genome Hybridizations, Comparative Genomic Hybridizations, CG2684, Fs(3)Horka, cancer of the large bowel, microarray, assay, cancer of large intestine, somatic mutation, colorectal (colon or rectal) cancer, Tumors, Cancer"],"additional_accession":[]},"is_claimable":false,"name":"Unsupervised Analysis of Array Comparative Genomic Hybridization Data from Early-Onset Colorectal Cancer Reveals Equivalence with Molecular Classification and Phenotypes","description":"Unsupervised Analysis of Array Comparative Genomic Hybridization Data from Early-Onset Colorectal Cancer Reveals Equivalence with Molecular Classification and Phenotypes","dates":{"last_updated":"2025-09-24","first_public":"2019-12-21"},"accession":"PRJNA422888","cross_references":{"GEO":["GSE108220"],"taxon":["9606"]}}