ENAGenomicsAB lineSoochow Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA429858Danio rerioPatients taking glucocorticoid or glucocorticoid-like drugs for an extended period of time can develop osteoporosis, termed glucocorticoid-induced osteoporosis (GIOP). GIOP is the most common form of secondary osteoporosis, but the mechanism underlying its development is unclear. In the present study, we used prednisolone to treat zebrafish larvae to investigate GIOP. Our RNA deep-sequencing (RNA-seq) results show that prednisolone affects genes known to act in the extracellular region, and therefore the extracellular region, extracellular matrix, and collagen trimer might be involved in glucocorticoid-induced osteoporosis.ENAzebra fish <Danio rerio>, zebra fish, Svc, Danio rerio (Hamilton, Bru, Zebra, leopard danio, Danio rerio, Zebra Fish, Col4a-1, Raw, Danio frankei, Zebrafishes, Sprain, Fishes, Cyprinus rerio Hamilton, danio, Zebra danios, ecotype, strain, Zebra danio, zebra danio, B. rerio, Danio rerio frankei, 1822), Zebra Fishes, Strain, 1822, D. rerio, sequence, Brachydanio rerio, primary structure of sequence macromolecule., cultivar, Strains, Del(8)44H, Cyprinus rerio, Brachidanio rerio, Sprains, Strains and Sprains, zebrafish, D. rerios, Brachydanio rerio frankeizebra fish <Danio rerio>, zebra fish, Danio rerio (Hamilton, Zebra, leopard danio, Danio rerio, Zebra Fish, Danio frankei, Zebrafishes, Sprain, Fishes, Cyprinus rerio Hamilton, danio, Zebra danios, ecotype, strain, Zebra danio, zebra danio, B. rerio, Danio rerio frankei, 1822), Zebra Fishes, 1822, D. rerio, Brachydanio rerio, Strain., cultivar, Strains, Cyprinus rerio, Brachidanio rerio, Sprains, Strains and Sprains, zebrafish, D. rerios, Brachydanio rerio frankeifalseDanio rerio strain:AB lineDanio rerio strain:AB line Raw sequence reads2025-09-242018-03-01PRJNA4298587955