{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/007/SRR6677397/SRR6677397.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/006/SRR6677396/SRR6677396.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/002/SRR6677392/SRR6677392.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/003/SRR6677393/SRR6677393.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/001/SRR6677391/SRR6677391.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/005/SRR6677395/SRR6677395.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/004/SRR6677394/SRR6677394.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR667/000/SRR6677390/SRR6677390.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Magnuson, Genetics, University of North Carolina at Chapel Hill"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA433181"],"scientific_name":["Mus musculus"],"long_description":["Obesity in humans is associated with worsened health outcomes following infections compared to non-obese individuals. Here, we examined the effects of adipose tissue and obesity on T cell responses to virus infection in mice. Lymphocytic choriomeningitis virus (LCMV) grew to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory CD4+ and CD8+ T cells residing in adipose were abundant, accounting for roughly 10% of all virus-specific memory T cells. Diet-induced obesity increased memory T cell number in adipose and spleen. Upon re-challenge infection, memory T cells caused severe pathogenesis, leading to sharply increased lipase levels, calcification of adipose tissue, pancreatitis, and reduced survival in obese mice but not lean mice. Thus, obesity leads to a unique form of viral pathogenesis involving memory T cell-dependent adipocyte destruction and collateral damage to other tissues. Overall design: RNA-seq comparison of CD4+ T cells in spleen vs fat (with 10 mice pooled per replicate) and CD8+ T cells in spleen vs fat (with 5 mice pooled per replicate)"],"tag":["xref:PubMed:30970254"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Obesity expands a distinct population of adipose-resident T cells and increases vulnerability to infection","description":"Obesity expands a distinct population of adipose-resident T cells and increases vulnerability to infection","dates":{"last_updated":"2025-09-24","first_public":"2019-03-21"},"accession":"PRJNA433181","cross_references":{"GEO":["GSE110212"],"taxon":["10090"],"PubMed":["30970254"]}}