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Medicine, University of California, San Diego"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA485140"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:30206152","xref:PubMed:36097162"],"long_description":["Interpretation of genome-wide investigations of host-pathogen interactions are often obscured by analyses of mixed populations of infected and uninfected cells. Thus, we developed a system whereby we simultaneously characterize and compare genome-wide transcriptional and epigenetic changes in pure populations of virally-infected and neighboring uninfected cells to identify viral-regulated host-responses. Using patient-derived unmodified Zika viruses (ZIKV) infecting primary human macrophages, we reveal that ZIKV suppresses host transcription by multiple mechanisms. ZIKV infection causes both targeted suppression of type I interferon responses and general suppression by reducing RNA polymerase II protein levels and DNA occupancy. Simultaneous evaluation of transcriptomic and epigenetic features of infected and uninfected cells provide a powerful method for identifying coincident evolution of dominant pro-viral or anti-viral mechanisms. Overall design: Analysis of transcriptional and epigenetic response of human monocyte derived macrophages to Zika virus infection"],"repository":["ENA"],"name_synonyms":["macrophagocyte, Disease, human being, mononuclear leukocyte, wide/broad, determination, Monocyte Derived Macrophages, Zika Fever, typical plasmatocyte, Modern, ZikV Infection, RNA-seq, Virus Infection, Monocyte Derived, broad, monocyte-derived macrophage, Virus Disease, Human, Monocyte-Derived, Zika Virus, Homo sapiens, macrophage, Congenital Zika Syndrome, chemical analysis, Monocyte-Derived Macrophage, Infection, congenital Zika virus infection, Whole Transcriptome Shotgun Sequencing, agranular plasmatocyte, Man, Congenital Zika Virus Infection, Monocyte-Derived Macrophages, Macrophage, congenital Zika syndrome, Man (Taxonomy), Genomes, Epigenetic, Macrophages, Zika, Zika Virus Disease, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, whole genome, man, human, Epigenomic, Bone Marrow-Derived, wide, Monocyte, lamellocyte, Modern Man, Fever, Bone Marrow-Derived Macrophages, granulocyte, ZikV, Zika Virus., assay, histiocyte, Epigenetics, monocyte, nongranular leukocyte"],"description_synonyms":["macrophagocyte, Disease, human being, mononuclear leukocyte, wide/broad, determination, Monocyte Derived Macrophages, Zika Fever, typical plasmatocyte, Modern, ZikV Infection, RNA-seq, Virus Infection, Monocyte Derived, broad, monocyte-derived macrophage, Virus Disease, Human, Monocyte-Derived, Zika Virus, Homo sapiens, macrophage, Congenital Zika Syndrome, chemical analysis, Monocyte-Derived Macrophage, Infection, congenital Zika virus infection, Whole Transcriptome Shotgun Sequencing, agranular plasmatocyte, Man, Congenital Zika Virus Infection, Monocyte-Derived Macrophages, Macrophage, congenital Zika syndrome, Man (Taxonomy), Genomes, Epigenetic, Macrophages, Zika, Zika Virus Disease, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, whole genome, man, human, Epigenomic, Bone Marrow-Derived, wide, Monocyte, lamellocyte, Modern Man, Fever, Bone Marrow-Derived Macrophages, granulocyte, ZikV, Zika Virus., assay, histiocyte, Epigenetics, monocyte, nongranular leukocyte"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide RNA-seq and Epigenetic analysis of human monocyte derived macrophage responses to Zika virus infection","description":"Genome-wide RNA-seq and Epigenetic analysis of human monocyte derived macrophage responses to Zika virus infection","dates":{"last_updated":"2025-09-22","first_public":"2018-09-11"},"accession":"PRJNA485140","cross_references":{"GEO":["GSE118305"],"taxon":["9606"],"PubMed":["36097162","30206152"]}}