ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/005/SRR7692415/SRR7692415.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/000/SRR7692400/SRR7692400.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/009/SRR7692409/SRR7692409.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/007/SRR7692417/SRR7692417.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/001/SRR7692421/SRR7692421.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/003/SRR7692413/SRR7692413.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/002/SRR7692402/SRR7692402.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/009/SRR7692419/SRR7692419.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/002/SRR7692422/SRR7692422.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/005/SRR7692405/SRR7692405.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/003/SRR7692403/SRR7692403.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/008/SRR7692408/SRR7692408.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/006/SRR7692416/SRR7692416.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/001/SRR7692411/SRR7692411.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/001/SRR7692401/SRR7692401.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/004/SRR7692414/SRR7692414.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/000/SRR7692420/SRR7692420.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/008/SRR7692418/SRR7692418.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/006/SRR7692406/SRR7692406.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/009/SRR7692399/SRR7692399.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/007/SRR7692407/SRR7692407.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/000/SRR7692410/SRR7692410.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/002/SRR7692412/SRR7692412.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR769/004/SRR7692404/SRR7692404.fastq.gzprimaryOK200GenomicsBermick, Pediatrics, University of Iowahttps://www.ebi.ac.uk/ena/browser/view/PRJNA485976Mus musculusxref:PubMed:31840058We report that TNFalpha mediated dendritic cell priming via alterations in histone 3 lysine 4 trimethylation (H3K4me3) sustains lasting protective Th1/Th17 responses during invasive Cryptococcus neoformans pulmonary infection. Cryptococcus neoformans pulmonary infection results in increased global lung dendritic cell H3K4me3 over naive lung dendritic cells. Blockage of TNFalpha during Cryptococcus neoformans pulmonary infection results in decreased H3K4me3 at sites crucial to protective Th1/Th17 responses. Overall design: Examination of H3K4me3 in lung CD11c+ dendritic cells in 4 different conditionsENAparent ion, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, Drives, establishment of T-lymphocyte polarity, Cachectin-Tumor Necrosis Factor, Epigenetic, Tumor Necrosis Factor alpha, TNFalpha, Cachectin Tumor Necrosis Factor, precursor, TNF Superfamily, T lymphocyte polarization, Epigenomic, DIF, T-cell polarization, TNF-a, establishment of T lymphocyte polarity., precursor ion, Member 2, TNFSF2, Tnfa, establishment of T-cell polarity, Epigenetics, T cell polarization, activation, Tnfsf1a, Tumor Necrosis Factorparent ion, Cachectin, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, Drives, establishment of T-lymphocyte polarity, Cachectin-Tumor Necrosis Factor, Epigenetic, Tumor Necrosis Factor alpha, TNFalpha, Cachectin Tumor Necrosis Factor, precursor, TNF Superfamily, T lymphocyte polarization, Epigenomic, DIF, T-cell polarization, TNF-a, establishment of T lymphocyte polarity., precursor ion, Member 2, TNFSF2, Tnfa, establishment of T-cell polarity, Epigenetics, T cell polarization, activation, Tnfsf1a, Tumor Necrosis FactorfalseEpigenetic stabilization of DC and DC precursor classical activation by TNFalpha drives protective T-cell polarizationEpigenetic stabilization of DC and DC precursor classical activation by TNFalpha drives protective T-cell polarization2025-09-242018-08-16PRJNA485976GSE1185431009031840058