{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/000/SRR7785380/SRR7785380_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/004/SRR7785384/SRR7785384_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/003/SRR7785383/SRR7785383_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/009/SRR7785379/SRR7785379_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/002/SRR7785382/SRR7785382_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/002/SRR7785382/SRR7785382_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/001/SRR7785381/SRR7785381_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/004/SRR7785384/SRR7785384_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/000/SRR7785380/SRR7785380_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/009/SRR7785379/SRR7785379_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/001/SRR7785381/SRR7785381_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/003/SRR7785383/SRR7785383_1.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Department of Haematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA489308"],"long_description":["Our group established Tg (Tol-GFP-EVI-1) zebrafish line and detected survival rate and developmental abnormality in injected embryos. And we found Tg (Tol-GFP-EVI-1) zebrafish embryos underwent abnormal hematopoiesis and aberrant expression of human EVI-1 perturbs hematopoiesis to promote myeloid myeloid and suppress erythroid lineage fates. Moreover, overexpression of human EVI-1 induced immature hematopoietic cells emerged in blood circulation. We used whole genome transcriptome analysis (RNA-Seq) to determine differential gene expression in peripheral blood between wildtype larvae and EVI-1 transgenic zebrafish larvae."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Over-expression of EVI-1 oncogene regulate multi-pathway to affect zebrafish embryogenesis and hemopoiesis","dates":{"last_updated":"2023-05-19","first_public":"2019-09-21"},"accession":"PRJNA489308","cross_references":{}}