ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/000/SRR7785380/SRR7785380_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/004/SRR7785384/SRR7785384_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/003/SRR7785383/SRR7785383_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/009/SRR7785379/SRR7785379_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/002/SRR7785382/SRR7785382_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/002/SRR7785382/SRR7785382_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/001/SRR7785381/SRR7785381_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/004/SRR7785384/SRR7785384_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/000/SRR7785380/SRR7785380_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/009/SRR7785379/SRR7785379_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/001/SRR7785381/SRR7785381_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR778/003/SRR7785383/SRR7785383_1.fastq.gzprimaryOK200GenomicsDepartment of Haematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA489308Our group established Tg (Tol-GFP-EVI-1) zebrafish line and detected survival rate and developmental abnormality in injected embryos. And we found Tg (Tol-GFP-EVI-1) zebrafish embryos underwent abnormal hematopoiesis and aberrant expression of human EVI-1 perturbs hematopoiesis to promote myeloid myeloid and suppress erythroid lineage fates. Moreover, overexpression of human EVI-1 induced immature hematopoietic cells emerged in blood circulation. We used whole genome transcriptome analysis (RNA-Seq) to determine differential gene expression in peripheral blood between wildtype larvae and EVI-1 transgenic zebrafish larvae.ENAfalseOver-expression of EVI-1 oncogene regulate multi-pathway to affect zebrafish embryogenesis and hemopoiesis2023-05-192019-09-21PRJNA489308