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and Molecular Genetics, American University of Beiruthttps://www.ebi.ac.uk/ena/browser/view/PRJNA494237Homo sapiensxref:PubMed:31266503We identified a chromatin displacement signature for the bromodomain proteins BRD2, BRD3 and BRD4 at TSS following treatment with I-BET152, an inhibitor of BET proteins. By integrating ChIP-seq, RNA-seq and Chem-seq data, we correlated alteration of the BRD4 signature at TSS with strong downregulation of gene expression which will facilitate identification of markers of sensitivity and resistance to drug. Overall design: Examination of drug effect on chromatin bound proteins of sensitive and resitant cell linesENAfalseQuantitative analysis of bi-modal binding of BET proteins at promoters predicts I-BET sensitivityQuantitative analysis of bi-modal binding of BET proteins at promoters predicts I-BET sensitivity2025-09-242019-07-23PRJNA494237GSE120715960631266503