ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/001/SRR8352531/SRR8352531_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/002/SRR8352532/SRR8352532_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/009/SRR8352529/SRR8352529_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/009/SRR8352529/SRR8352529_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/000/SRR8352530/SRR8352530_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/003/SRR8352533/SRR8352533_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/002/SRR8352532/SRR8352532_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/000/SRR8352530/SRR8352530_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/003/SRR8352533/SRR8352533_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR835/001/SRR8352531/SRR8352531_1.fastq.gzprimaryOK200GenomicsLinxin lab, school of medicine, Tsinghua universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA510753Mus musculusWe report that the paracaspase Malt1 is required for the development and function of Treg cells. By generating Malt1 conditional knockout and protease dead mutant mice, we found Malt1-loss in Treg cells would lead to early-onset lethal autoimmune disease and the mice would die within 40 days after birth. Interestingly, mice with Treg specific inhibition of Malt1 protease activity develop spontaneous inflammatory disorders. Overall design: YFP+ Treg cells sorted from WT, cKO and cKI mice were used for RNA extraction and RNA-sequencingENAregulatory T lymphocyte, Immune Processes, Immune Responses, Malignant Neoplasm, suppressor T lymphocyte, alpha-beta regulatory T-cell, Malignancy, Process, D430033E09Rik, Neoplasms, CD4-positive, Benign Neoplasm, MLT, A630046N12, Benign Neoplasms, function, regulatory T-cell, Cancers, MLT1, Tumor, Malignant, suppressor T cell, Cell, Malignant Neoplasms, alpha-beta regulatory T-lymphocyte, suppressor T-cell, Neoplasias, suppressor T-lymphocyte, Immune Response, Immune, Treg, Benign, IMD12, regulatory T-lymphocyte, mlt1, alpha-beta regulatory T lymphocyte, Neoplasm, Response, mlt, Malignancies, CD25-positive, Immune., other neoplasm, Immune Process, Neoplasia, Cancer, Tumorsregulatory T lymphocyte, Immune Processes, Immune Responses, Malignant Neoplasm, suppressor T lymphocyte, alpha-beta regulatory T-cell, Malignancy, Process, D430033E09Rik, Neoplasms, CD4-positive, Benign Neoplasm, MLT, A630046N12, Benign Neoplasms, function, regulatory T-cell, Cancers, MLT1, Tumor, Malignant, suppressor T cell, Cell, Malignant Neoplasms, alpha-beta regulatory T-lymphocyte, suppressor T-cell, Neoplasias, suppressor T-lymphocyte, Immune Response, Immune, Treg, Benign, IMD12, regulatory T-lymphocyte, mlt1, alpha-beta regulatory T lymphocyte, Neoplasm, Response, mlt, Malignancies, CD25-positive, Immune., other neoplasm, Immune Process, Neoplasia, Cancer, TumorsfalseMalt1 protease is critical in maintaining function of Treg cells and may be a therapeutic target for anti-tumor immunityMalt1 protease is critical in maintaining function of Treg cells and may be a therapeutic target for anti-tumor immunity2025-09-242019-01-03PRJNA510753GSE12408910090