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Sloan Kettering Cancer Centerhttps://www.ebi.ac.uk/ena/browser/view/PRJNA523232Mus musculusxref:PubMed:31027997Stable changes in chromatin states and gene expression in cells of the immune system form the basis for their memory of infections and other challenges. We used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore the mechanisms underlying long-lasting vs. transient gene regulation in antigen-specific CD8 T cells responding to acute viral infection. Our observations provide novel insights into the mechanisms driving stable and reversible transcriptional and epigenetic memory in virus-specific CD8 T cells. These findings suggest a general mechanism for the formation of epigenetic memory in CD8 T cells and other immune and non-immune cells. Overall design: The project studied the chromatin accessibility and gene transcription of CD8+ T cell in response to viral infection. 70 samples were analysed in total, including 22 ATAC-Seq, 29 RNA-Seq, 18 ChIP-Seq and 1 single cell RNA-Seq samples.ENAfalseNatural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cellsNatural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells2025-09-242019-05-23PRJNA523232GSE1267701009031027997