{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR864/008/SRR8645868/SRR8645868.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR864/005/SRR8645865/SRR8645865.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR864/007/SRR8645867/SRR8645867.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR864/006/SRR8645866/SRR8645866.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Biochemistry and Molecular Genetics, University of Colorado School of Medicine"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA524710"],"scientific_name":["Mus musculus"],"long_description":["A known human SNP in the matrix-binding domain of extracellular superoxide dismutase (EC-SOD), with an arginine to glycine substitution at position 213 (R213G), redistributes EC-SOD from the matrix into extracellular fluids. We reported that, following bleomycin (bleo), knock-in mice harboring the human R213G SNP (R213G mice), compared to wild-type (WT) littermates exhibit enhanced resolution of inflammation and protection against fibrosis. We tested the hypothesis that the EC-SOD R213G SNP promotes resolution via accelerated apoptosis of recruited alveolar macrophage (recAM). Overall design: RNA-seq of alveolar macrophages populations in response to bleomycin"],"tag":["xref:PubMed:31560857"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Redistribution of EC-SOD due to the R213G SNP reveals differential RNA-seq profile of recruited alveolar macrophages and accelerated apoptosis in response to bleomycin","description":"Redistribution of EC-SOD due to the R213G SNP reveals differential RNA-seq profile of recruited alveolar macrophages and accelerated apoptosis in response to bleomycin","dates":{"last_updated":"2025-09-24","first_public":"2022-02-03"},"accession":"PRJNA524710","cross_references":{"GEO":["GSE127345"],"taxon":["10090"],"PubMed":["31560857"]}}