{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/003/SRR8723383/SRR8723383_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/004/SRR8723384/SRR8723384_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/002/SRR8723382/SRR8723382_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/001/SRR8723381/SRR8723381_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/005/SRR8723385/SRR8723385_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/001/SRR8723391/SRR8723391_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/000/SRR8723390/SRR8723390_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/009/SRR8723389/SRR8723389_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/008/SRR8723388/SRR8723388_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/005/SRR8723395/SRR8723395_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/004/SRR8723394/SRR8723394_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/009/SRR8723389/SRR8723389_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/002/SRR8723392/SRR8723392_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/007/SRR8723387/SRR8723387_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/006/SRR8723386/SRR8723386_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/008/SRR8723388/SRR8723388_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/003/SRR8723393/SRR8723393_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/001/SRR8723391/SRR8723391_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/000/SRR8723390/SRR8723390_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/004/SRR8723394/SRR8723394_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/002/SRR8723382/SRR8723382_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/003/SRR8723393/SRR8723393_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/001/SRR8723381/SRR8723381_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/000/SRR8723380/SRR8723380_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/002/SRR8723392/SRR8723392_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/006/SRR8723386/SRR8723386_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/007/SRR8723387/SRR8723387_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/003/SRR8723383/SRR8723383_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/000/SRR8723380/SRR8723380_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/005/SRR8723395/SRR8723395_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/004/SRR8723384/SRR8723384_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR872/005/SRR8723385/SRR8723385_2.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Northwestern University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA526892"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:32094355"],"long_description":["Down-regulation of genes belonging to the JUN, FOS, and ATF families of transcription factors has previously been described. In this study, we demonstrate that the loss of AP-1 subunit gene expression leads to a decrease in AP-1 enhancer occupancy. Knockdown of AP-1 subunits demonstrates that loss of AP-1 subunit gene expression results in a perturbation of extracellular matrix-associated gene expression. This work establishes AP-1 as an important transcription factor in uterine leiomyoma disease pathogenesis. Overall design: RNA profiles of negative control and AP-1 knockdown in myometrium primary cells derived from 2 patient tissue samples were generated by deep sequencing."],"repository":["ENA"],"description_synonyms":["uterine myometrium, D-jun/Jra, CG33956, GOS3, Activator Protein 1, determination, AP-1, d-jun, cJun, number, p55, l(2)46Ef, fra, Gene, D-fos, DmelCG33956, GOSB, gamma-Ada, Transcription Factor AP 1, jra, presence, prevention, Enhancer-Binding Protein, Dfos, cg9113, DFra, AP-1 Enhancer-Binding Protein, prevention and control, dJRA, dJra, fbz, dFra, dFRA, CG15507, CG15509, Junc, tunica muscularis, simple tissue., Gene Expressions, reference sample, dlhD, l(2)IA109, dJun, dJUN, Tissue, V, DmelCG9113, Expressions, Uterine Muscle, preventive measures, Jun, JUN, DmelCG2275, Muscles, Clients, c-Jun, D-Fos, AP-1[gamma], l(2R)IA109, Expression, d-fos, gamma, Controlled, jun, Controlling, Uterine Muscles, d-JRA, preventive therapy, D-Jun, c-jun, AP1gamma, Muscle, Activator Protein-1, Uterine, Client, Cell, AP 1 Enhancer Binding Protein, Djun, count in organism, dm-Jun, FOS, Fos, uterine smooth muscle, chemical analysis, D-jun, djun, dgamma, DJUN, DJun, Kay, D-fos/kay, c-Fos, CG9113, dfos, fos, prophylaxis, AP1gamma1, CG2275, patient, AP1, C-FOS, G0S3, dAP-1, dFos, AP-1 Enhancer Binding Protein, c-fos, Patient, control, d-Jun, Fra, assay, JRA, DFos, DFOS"],"name_synonyms":["uterine myometrium, D-jun/Jra, CG33956, GOS3, Activator Protein 1, determination, AP-1, d-jun, cJun, number, p55, l(2)46Ef, fra, Gene, D-fos, DmelCG33956, GOSB, gamma-Ada, Transcription Factor AP 1, jra, presence, prevention, Enhancer-Binding Protein, Dfos, cg9113, DFra, AP-1 Enhancer-Binding Protein, prevention and control, dJRA, dJra, fbz, dFra, dFRA, CG15507, CG15509, Junc, tunica muscularis, simple tissue., Gene Expressions, reference sample, dlhD, l(2)IA109, dJun, dJUN, Tissue, V, DmelCG9113, Expressions, Uterine Muscle, preventive measures, Jun, JUN, DmelCG2275, Muscles, Clients, c-Jun, D-Fos, AP-1[gamma], l(2R)IA109, Expression, d-fos, gamma, Controlled, jun, Controlling, Uterine Muscles, d-JRA, preventive therapy, D-Jun, c-jun, AP1gamma, Muscle, Activator Protein-1, Uterine, Client, Cell, AP 1 Enhancer Binding Protein, Djun, count in organism, dm-Jun, FOS, Fos, uterine smooth muscle, chemical analysis, D-jun, djun, dgamma, DJUN, DJun, Kay, D-fos/kay, c-Fos, CG9113, dfos, fos, prophylaxis, AP1gamma1, CG2275, patient, AP1, C-FOS, G0S3, dAP-1, dFos, AP-1 Enhancer Binding Protein, c-fos, Patient, control, d-Jun, Fra, assay, JRA, DFos, DFOS"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative analysis of AP-1 dependent gene expression in negative control and AP-1 knockdown myometrium primary cells derived from 2 patient tissue samples.","description":"Quantitative analysis of AP-1 dependent gene expression in negative control and AP-1 knockdown myometrium primary cells derived from 2 patient tissue samples.","dates":{"last_updated":"2025-09-24","first_public":"2020-01-03"},"accession":"PRJNA526892","cross_references":{"GEO":["GSE128237"],"taxon":["9606"],"PubMed":["32094355"]}}