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Institute of Arthritis and Musculoskeletal and Skin Diseaseshttps://www.ebi.ac.uk/ena/browser/view/PRJNA527213mouse skin metagenomexref:EuropePMC:PMC6628910Vitamin A deficiency increases susceptibility to skin infection yet how vitamin A regulates skin immunity remains unclear. Here, we show that resistin-like molecule alpha (RELMa) is a skin antimicrobial protein that is required for vitamin A-dependent resistance to skin infection. RELMa was induced in mouse skin by bacterial colonization, killed skin bacteria in vitro, and protected against bacterial infection of the skin in vivo. The 16S small subunit ribosomal (rRNA) gene is present in every bacterial cell, serving as a universal marker. The gene is sufficiently conserved to allow accurate alignment but adequately varied to enable phylogenetic analyses. We examined the bacterial diversity of skin in the presence/absence of RELMa using a 16S rRNA surveyENAdermis plus epidermis plus hypodermis, 3.4.22.-, the integument, alpha-Ada, anon-EST:fe2E2, region of skin, BamF, l(3)alpha-Spec, pelt, BamC, AP-2, Laboratory, Otf-11, Skn-li, Mus domesticus, alpha-Spect, alpha-Spe, Gene, mini-ICE, CASP-14, CG31654, alpha-Spc, House Mouse, l(2)SH2 0460, epidermis, fs(3)neo61, CG10422, alpha-ada, l(3)04276, House, RNA Genes, Adipocyte Cysteine Rich Secreted Protein FIZZ3, klo, Mus musculus domesticus, rRNA Genes, alpha-adaptin, alpha-Sp, DmelCG10422, CG1977, Mice, integumentum commune, alpha-spec, Skn-1a, Ribosomal, Ribosomal RNA Gene, skin, CG4260, Swiss, dermoid system, entire skin, dre3, Ribosomal RNA, Swiss Mice, Alpha-Adaptin, SKIN, alpha-spectrin, skin organ, Fam91a1, Otf11, rDNA, AV220772, skin and subcutaneous tissue, l(3)dre3, Oct-11a, alpha-Spectrin, 3A9, DmelCG1977, CASP14, mouse, skin zone, ham, integumental organ, Resistin, ada, skin plus hypodermis, alphaSpec, D-Ada, Ribosomal RNA Genes, Oct11, skin region, Mus, BC033609, Mini-ICE, cg4260, MENE(2L)-A, dAP-2a, Skin-1a, tegument, alphaSp, Skin, spectrin, Mus musculus., skin benign neoplasm, l(2)06694, MENE (2L)-A, Mus musculus, Genes, D-alphaAda, mating_type_alpha, Caspase-14 subunit p10, mice, Swiss Mouse, vertebrate integument, FCP-B, House Mice, Caspase-14 subunit p19, alpha, AP-2alpha, MICE, rRNA gene, mKIAA0493, DmelCG4260, Epoc-1, Adipocyte Cysteine-Rich Secreted Protein FIZZ3, Laboratory Mice, domesticus, portion of skin, AP2, vertebrate epidermis, RNA Gene, rRNA, integument, l(3)62Bd, Bam-C, rRNA Gene, BAM, Bam, alpha mating type (yeast), l(2)SH0460, alfa-Spec, Mouse, entire integument, dermal system, Laboratory Mouse, Specdermis plus epidermis plus hypodermis, the integument, region of skin, Oct-11a, pelt, Laboratory, Otf-11, Skn-li, Mus domesticus, mouse, skin zone, integumental organ, House Mouse, epidermis, skin plus hypodermis, Metagenomes., Oct11, skin region, House, Mus, BC033609, Mus musculus domesticus, Skin-1a, tegument, Mice, Skin, integumentum commune, Skn-1a, skin benign neoplasm, Mus musculus, skin, Swiss, mice, Swiss Mouse, vertebrate integument, dermoid system, entire skin, House Mice, Swiss Mice, SKIN, mKIAA0493, domesticus, Laboratory Mice, Epoc-1, skin organ, portion of skin, vertebrate epidermis, integument, Fam91a1, Otf11, Mouse, house mouse, entire integument, AV220772, dermal system, Laboratory Mouse, skin and subcutaneous tissuefalsemouse skin metagenome16S rRNA gene sequences amplified from the skin of WT and resistin-like molecule (RELM) alpha deficient mice2024-03-302019-05-02PRJNA527213540485