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Here, we leverage the translocation mechanism of an antimicrobial guanidinium-functionalized polycarbonate in combination with traditional antibiotics to afford a strong synergistic treatment for drug-resistant bacteria. This polymer-antibiotic combination approach reverses rifampicin resistance in A. baumannii demonstrating a 2.5×105 folds reduction in MIC. This approach also enables the repurposing of auranofin as antibiotic against multidrug-resistant (MDR) Gram-negative bacteria with a 500-fold MIC reduction. Finally, the in vivo efficacy of polymer-rifampicin combination is demonstrated in a MDR bacteremia mouse model. This combination approach lays foundational ground rules for a new class of antibiotic adjuvants capable of reversing drug resistance and enhancing potency of common antibiotics against MDR bacteria."],"tag":["xref:EuropePMC:PMC7503100"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Antibiotic/Macromolecule Combination Reverses Antibiotic Resistance and Promotes Synergy","dates":{"last_updated":"2023-05-19","first_public":"2020-06-02"},"accession":"PRJNA543935","cross_references":{}}