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1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR911/007/SRR9117997/SRR9117997_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR911/002/SRR9117992/SRR9117992_1.fastq.gzprimaryOK200GenomicsWenzhou Medical Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA544626Homo sapiensxref:PubMed:32162843Transcriptome profiling is a sensitive strategy to uncover the change of mitochondrial to nucleus signaling due to the minor alternation of mitochondrial OXPHOS function. Therefore, we hypothesized that even a minor alternation of OXPHOS function can also remold transcriptome profiles in m.14487T>C mutant cybrid when compared with control cybrids. Our data suggest that a comparable mitochondrial OXPHOS function between m.14487T and m.14487C cybrids is not because of compensatory boost of mitochondrial biogenesis in m.14487C cybrids. Overall design: Examination of cybrids cells with and without m.14487T>C mutation from three different patients by deep sequencing,in triplicate,using Illumina Hiseq 2000.ENAfalseTranscriptome profiling of cybrids cells with and without m.14487T>C mutationTranscriptome profiling of cybrids cells with and without m.14487T>C mutation2025-09-242020-05-21PRJNA544626GSE131739960632162843