ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/043/SRR10668843/SRR10668843_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/030/SRR10668930/SRR10668930_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/001/SRR10668801/SRR10668801_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR109/042/SRR10902842/SRR10902842_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/094/SRR10668894/SRR10668894_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/026/SRR10668926/SRR10668926_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/031/SRR10668931/SRR10668931_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/016/SRR10668916/SRR10668916_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/084/SRR10668884/SRR10668884_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/049/SRR10668849/SRR10668849_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/028/SRR10668828/SRR10668828_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/032/SRR10668832/SRR10668832_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/037/SRR10668937/SRR10668937_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/042/SRR10668842/SRR10668842_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/002/SRR10668802/SRR10668802_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/005/SRR10668905/SRR10668905_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/073/SRR10668873/SRR10668873_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/020/SRR10668920/SRR10668920_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/068/SRR10668868/SRR10668868_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/004/SRR10668904/SRR10668904_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/009/SRR10668809/SRR10668809_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/069/SRR10668869/SRR10668869_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/083/SRR10668883/SRR10668883_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/041/SRR10668941/SRR10668941_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/011/SRR10668911/SRR10668911_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/008/SRR10668808/SRR10668808_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/054/SRR10668854/SRR10668854_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/053/SRR10668853/SRR10668853_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/027/SRR10668927/SRR10668927_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/006/SRR10668806/SRR10668806_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/042/SRR10668942/SRR10668942_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/021/SRR10668821/SRR10668821_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/024/SRR10668824/SRR10668824_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/023/SRR10668823/SRR10668823_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/020/SRR10668820/SRR10668820_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/039/SRR10668839/SRR10668839_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/038/SRR10668838/SRR10668838_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/022/SRR10668922/SRR10668922_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/051/SRR10668851/SRR10668851_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/034/SRR10668934/SRR10668934_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/099/SRR10668799/SRR10668799_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/005/SRR10668805/SRR10668805_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/034/SRR10668834/SRR10668834_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/019/SRR10668919/SRR10668919_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/061/SRR10668861/SRR10668861_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/046/SRR10668846/SRR10668846_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/099/SRR10668899/SRR10668899_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/087/SRR10668887/SRR10668887_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/010/SRR10668810/SRR10668810_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/004/SRR10668804/SRR10668804_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/007/SRR10668907/SRR10668907_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/016/SRR10668816/SRR10668816_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/046/SRR10668846/SRR10668846_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/040/SRR10668840/SRR10668840_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/076/SRR10668876/SRR10668876_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/091/SRR10668891/SRR10668891_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/019/SRR10668819/SRR10668819_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/088/SRR10668888/SRR10668888_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/058/SRR10668858/SRR10668858_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/019/SRR10668919/SRR10668919_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/076/SRR10668876/SRR10668876_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/025/SRR10668825/SRR10668825_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/064/SRR10668864/SRR10668864_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/001/SRR10668901/SRR10668901_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/013/SRR10668913/SRR10668913_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/031/SRR10668831/SRR10668831_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/034/SRR10668934/SRR10668934_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/016/SRR10668816/SRR10668816_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/013/SRR10668813/SRR10668813_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/067/SRR10668867/SRR10668867_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/091/SRR10668891/SRR10668891_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/004/SRR10668904/SRR10668904_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/079/SRR10668879/SRR10668879_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/097/SRR10668897/SRR10668897_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/082/SRR10668882/SRR10668882_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/027/SRR10668827/SRR10668827_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/055/SRR10668855/SRR10668855_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/031/SRR10668831/SRR10668831_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/013/SRR10668813/SRR10668813_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/003/SRR10668803/SRR10668803_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/037/SRR10668837/SRR10668837_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/072/SRR10668872/SRR10668872_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/042/SRR10668942/SRR10668942_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/096/SRR10668896/SRR10668896_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/095/SRR10668895/SRR10668895_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/002/SRR10668902/SRR10668902_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/017/SRR10668917/SRR10668917_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/026/SRR10668926/SRR10668926_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/079/SRR10668879/SRR10668879_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/085/SRR10668885/SRR10668885_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/032/SRR10668932/SRR10668932_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/070/SRR10668870/SRR10668870_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/061/SRR10668861/SRR10668861_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR109/042/SRR10902842/SRR10902842_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/080/SRR10668880/SRR10668880_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/011/SRR10668811/SRR10668811_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/056/SRR10668856/SRR10668856_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/057/SRR10668857/SRR10668857_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/094/SRR10668894/SRR10668894_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/081/SRR10668881/SRR10668881_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/089/SRR10668889/SRR10668889_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/099/SRR10668799/SRR10668799_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/042/SRR10668842/SRR10668842_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/036/SRR10668836/SRR10668836_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/018/SRR10668818/SRR10668818_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/071/SRR10668871/SRR10668871_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/066/SRR10668866/SRR10668866_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/065/SRR10668865/SRR10668865_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/059/SRR10668859/SRR10668859_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/002/SRR10668802/SRR10668802_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/041/SRR10668841/SRR10668841_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/035/SRR10668835/SRR10668835_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/050/SRR10668850/SRR10668850_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/026/SRR10668826/SRR10668826_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/017/SRR10668817/SRR10668817_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/012/SRR10668812/SRR10668812_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/032/SRR10668832/SRR10668832_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/033/SRR10668833/SRR10668833_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/018/SRR10668918/SRR10668918_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/074/SRR10668874/SRR10668874_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/062/SRR10668862/SRR10668862_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/006/SRR10668906/SRR10668906_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/098/SRR10668898/SRR10668898_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/086/SRR10668886/SRR10668886_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/041/SRR10668941/SRR10668941_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/023/SRR10668923/SRR10668923_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/035/SRR10668935/SRR10668935_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/008/SRR10668908/SRR10668908_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/011/SRR10668911/SRR10668911_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/024/SRR10668924/SRR10668924_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/038/SRR10668938/SRR10668938_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/000/SRR10668900/SRR10668900_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/012/SRR10668912/SRR10668912_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/036/SRR10668936/SRR10668936_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/045/SRR10668945/SRR10668945_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/033/SRR10668933/SRR10668933_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/009/SRR10668909/SRR10668909_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/015/SRR10668915/SRR10668915_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/098/SRR10668798/SRR10668798_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/027/SRR10668927/SRR10668927_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/021/SRR10668921/SRR10668921_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/003/SRR10668903/SRR10668903_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/044/SRR10668944/SRR10668944_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/015/SRR10668815/SRR10668815_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/071/SRR10668871/SRR10668871_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/070/SRR10668870/SRR10668870_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/025/SRR10668825/SRR10668825_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/003/SRR10668903/SRR10668903_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/002/SRR10668902/SRR10668902_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/056/SRR10668856/SRR10668856_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/039/SRR10668939/SRR10668939_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/081/SRR10668881/SRR10668881_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/043/SRR10668943/SRR10668943_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/097/SRR10668897/SRR10668897_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/026/SRR10668826/SRR10668826_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/082/SRR10668882/SRR10668882_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/029/SRR10668929/SRR10668929_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/028/SRR10668928/SRR10668928_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/014/SRR10668914/SRR10668914_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/067/SRR10668867/SRR10668867_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/066/SRR10668866/SRR10668866_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/013/SRR10668913/SRR10668913_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/032/SRR10668932/SRR10668932_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/045/SRR10668845/SRR10668845_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/096/SRR10668896/SRR10668896_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/000/SRR10668800/SRR10668800_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/090/SRR10668890/SRR10668890_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/078/SRR10668878/SRR10668878_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/018/SRR10668918/SRR10668918_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/092/SRR10668892/SRR10668892_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/093/SRR10668893/SRR10668893_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/048/SRR10668848/SRR10668848_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/017/SRR10668917/SRR10668917_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/077/SRR10668877/SRR10668877_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/014/SRR10668814/SRR10668814_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/035/SRR10668935/SRR10668935_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/033/SRR10668933/SRR10668933_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/060/SRR10668860/SRR10668860_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/029/SRR10668829/SRR10668829_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/047/SRR10668847/SRR10668847_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/044/SRR10668844/SRR10668844_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/030/SRR10668830/SRR10668830_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/063/SRR10668863/SRR10668863_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/007/SRR10668907/SRR10668907_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/075/SRR10668875/SRR10668875_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/022/SRR10668822/SRR10668822_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/007/SRR10668807/SRR10668807_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/040/SRR10668940/SRR10668940_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/005/SRR10668905/SRR10668905_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/058/SRR10668858/SRR10668858_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/019/SRR10668819/SRR10668819_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/034/SRR10668834/SRR10668834_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/052/SRR10668852/SRR10668852_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/010/SRR10668810/SRR10668810_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/022/SRR10668822/SRR10668822_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/007/SRR10668807/SRR10668807_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/064/SRR10668864/SRR10668864_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/010/SRR10668910/SRR10668910_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/037/SRR10668837/SRR10668837_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/049/SRR10668849/SRR10668849_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/088/SRR10668888/SRR10668888_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/040/SRR10668940/SRR10668940_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/028/SRR10668828/SRR10668828_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/001/SRR10668801/SRR10668801_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/043/SRR10668843/SRR10668843_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/040/SRR10668840/SRR10668840_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/004/SRR10668804/SRR10668804_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/025/SRR10668925/SRR10668925_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/022/SRR10668922/SRR10668922_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/055/SRR10668855/SRR10668855_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/037/SRR10668937/SRR10668937_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/052/SRR10668852/SRR10668852_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/085/SRR10668885/SRR10668885_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/010/SRR10668910/SRR10668910_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/073/SRR10668873/SRR10668873_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/078/SRR10668878/SRR10668878_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/014/SRR10668914/SRR10668914_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/038/SRR10668938/SRR10668938_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/028/SRR10668928/SRR10668928_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/015/SRR10668915/SRR10668915_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/068/SRR10668868/SRR10668868_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/043/SRR10668943/SRR10668943_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/009/SRR10668809/SRR10668809_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/025/SRR10668925/SRR10668925_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/044/SRR10668844/SRR10668844_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/031/SRR10668931/SRR10668931_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/038/SRR10668838/SRR10668838_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/030/SRR10668830/SRR10668830_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/039/SRR10668839/SRR10668839_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/014/SRR10668814/SRR10668814_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/093/SRR10668893/SRR10668893_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/020/SRR10668820/SRR10668820_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/001/SRR10668901/SRR10668901_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/054/SRR10668854/SRR10668854_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/016/SRR10668916/SRR10668916_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/008/SRR10668908/SRR10668908_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/084/SRR10668884/SRR10668884_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/020/SRR10668920/SRR10668920_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/021/SRR10668921/SRR10668921_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/009/SRR10668909/SRR10668909_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/006/SRR10668906/SRR10668906_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/023/SRR10668923/SRR10668923_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/045/SRR10668945/SRR10668945_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/029/SRR10668929/SRR10668929_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/039/SRR10668939/SRR10668939_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/030/SRR10668930/SRR10668930_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/044/SRR10668944/SRR10668944_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/090/SRR10668890/SRR10668890_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/035/SRR10668835/SRR10668835_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/036/SRR10668936/SRR10668936_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/098/SRR10668798/SRR10668798_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/023/SRR10668823/SRR10668823_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/024/SRR10668924/SRR10668924_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/033/SRR10668833/SRR10668833_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/012/SRR10668912/SRR10668912_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/021/SRR10668821/SRR10668821_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/047/SRR10668847/SRR10668847_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/006/SRR10668806/SRR10668806_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/000/SRR10668900/SRR10668900_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/018/SRR10668818/SRR10668818_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/059/SRR10668859/SRR10668859_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/075/SRR10668875/SRR10668875_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/069/SRR10668869/SRR10668869_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/057/SRR10668857/SRR10668857_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/087/SRR10668887/SRR10668887_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/045/SRR10668845/SRR10668845_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/099/SRR10668899/SRR10668899_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/005/SRR10668805/SRR10668805_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/051/SRR10668851/SRR10668851_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/011/SRR10668811/SRR10668811_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/008/SRR10668808/SRR10668808_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/063/SRR10668863/SRR10668863_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/060/SRR10668860/SRR10668860_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/072/SRR10668872/SRR10668872_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/029/SRR10668829/SRR10668829_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/041/SRR10668841/SRR10668841_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/003/SRR10668803/SRR10668803_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/098/SRR10668898/SRR10668898_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/048/SRR10668848/SRR10668848_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/017/SRR10668817/SRR10668817_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/086/SRR10668886/SRR10668886_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/027/SRR10668827/SRR10668827_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/077/SRR10668877/SRR10668877_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/074/SRR10668874/SRR10668874_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/036/SRR10668836/SRR10668836_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/024/SRR10668824/SRR10668824_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/065/SRR10668865/SRR10668865_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/062/SRR10668862/SRR10668862_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/053/SRR10668853/SRR10668853_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/050/SRR10668850/SRR10668850_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/015/SRR10668815/SRR10668815_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/012/SRR10668812/SRR10668812_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/000/SRR10668800/SRR10668800_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/089/SRR10668889/SRR10668889_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/080/SRR10668880/SRR10668880_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/083/SRR10668883/SRR10668883_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/092/SRR10668892/SRR10668892_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR106/095/SRR10668895/SRR10668895_2.fastq.gzprimary200OKGenomicsCenter for Genes, Environment, and Health, National Jewish Healthhttps://www.ebi.ac.uk/ena/browser/view/PRJNA554141Homo sapiensCigarette smoke first interacts with the lung through the cellularly diverse airway epithelium and goes on to drive development of most chronic lung diseases. Here, through single cell RNA-sequencing analysis of the tracheal epithelium from smokers and nonsmokers, we generate a comprehensive atlas of epithelial cell types and states, connect these into lineages, and define cell-specific responses to smoking. Our analysis infers multi-state lineages that develop into surface mucus secretory and ciliated cells and then contrasts these to the unique specification of submucosal gland (SMG) cells. Accompanying knockout studies reveal that tuft-like cells are the likely progenitor of both pulmonary neuroendocrine cells and CFTR-rich ionocytes. Our smoking analysis finds that all cell types, including protected stem and SMG populations, are affected by smoking through both pan-epithelial smoking response networks and hundreds of cell-specific response genes, redefining the penetrance and cellular specificity of smoking effects on the human airway epithelium. Overall design: For the in vivo dataset, we sequenced a total of 68,370 (36,248 after QC) epithelial cells from across 15 human tracheal donors (6 heavy smokers, 6 never-smokers, 2 light smokers, and 1 pediatric subject). For the in vitro dataset we sequenced a total of 8,722 (5,976 after QC) epithelial cells sampled from 20 time points along the differentiation process taken by air-liquid interface (ALI) cultures seeded from primary basal cells of 3 human tracheal donors (from ALI seed day to day 32 post-airlift)xref:PubMed:32427931ENAfalseDissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epitheliumDissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium2025-09-242020-04-10PRJNA554141GSE134174960632427931