{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/044/SRR11396244/SRR11396244.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969174/SRR9969174.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969155/SRR9969155.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/027/SRR11396227/SRR11396227.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969193/SRR9969193.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969117/SRR9969117.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969136/SRR9969136.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969235/SRR9969235_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969186/SRR9969186.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/093/SRR11396193/SRR11396193_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969167/SRR9969167.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969216/SRR9969216_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969228/SRR9969228_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969129/SRR9969129.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/035/SRR11396235/SRR11396235.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969148/SRR9969148.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969179/SRR9969179.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969202/SRR9969202.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969198/SRR9969198.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/019/SRR11396219/SRR11396219.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969143/SRR9969143.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/097/SRR11396197/SRR11396197_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/026/SRR11396226/SRR11396226.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969237/SRR9969237_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969220/SRR9969220_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/098/SRR11396198/SRR11396198_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969225/SRR9969225_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969181/SRR9969181.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969162/SRR9969162.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/018/SRR11396218/SRR11396218.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969218/SRR9969218_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969105/SRR9969105.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/083/SRR11396183/SRR11396183_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/082/SRR11396182/SRR11396182_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969124/SRR9969124.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969170/SRR9969170.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969120/SRR9969120.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969229/SRR9969229_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969221/SRR9969221_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/043/SRR11396243/SRR11396243.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/090/SRR11396190/SRR11396190_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/087/SRR11396187/SRR11396187_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/028/SRR11396228/SRR11396228.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/010/SRR11396210/SRR11396210.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969240/SRR9969240_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/045/SRR11396245/SRR11396245.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969207/SRR9969207.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/034/SRR11396234/SRR11396234.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969100/SRR9969100.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/054/SRR11396254/SRR11396254.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969234/SRR9969234_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/090/SRR11396190/SRR11396190_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/001/SRR11396201/SRR11396201.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969132/SRR9969132.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969215/SRR9969215_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969112/SRR9969112.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969185/SRR9969185.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/096/SRR11396196/SRR11396196_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969230/SRR9969230_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969219/SRR9969219_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/052/SRR11396252/SRR11396252.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/053/SRR11396253/SRR11396253.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/036/SRR11396236/SRR11396236.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969237/SRR9969237_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969150/SRR9969150.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969147/SRR9969147.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969109/SRR9969109.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/051/SRR11396251/SRR11396251.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969238/SRR9969238_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969137/SRR9969137.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/000/SRR11396200/SRR11396200_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/037/SRR11396237/SRR11396237.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969175/SRR9969175.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969224/SRR9969224_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/029/SRR11396229/SRR11396229.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969210/SRR9969210.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969142/SRR9969142.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969149/SRR9969149.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969123/SRR9969123.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969218/SRR9969218_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969228/SRR9969228_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969173/SRR9969173.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969199/SRR9969199.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/082/SRR11396182/SRR11396182_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/042/SRR11396242/SRR11396242.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969116/SRR9969116.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969226/SRR9969226_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969192/SRR9969192.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/020/SRR11396220/SRR11396220.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/016/SRR11396216/SRR11396216.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/050/SRR11396250/SRR11396250.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/002/SRR11396202/SRR11396202.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969163/SRR9969163.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/024/SRR11396224/SRR11396224.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/041/SRR11396241/SRR11396241.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/000/SRR11396200/SRR11396200_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969106/SRR9969106.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969239/SRR9969239_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969231/SRR9969231_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/003/SRR11396203/SRR11396203.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969152/SRR9969152.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/025/SRR11396225/SRR11396225.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969223/SRR9969223_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/011/SRR11396211/SRR11396211.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969159/SRR9969159.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969242/SRR9969242_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/033/SRR11396233/SRR11396233.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969208/SRR9969208.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/091/SRR11396191/SRR11396191_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/086/SRR11396186/SRR11396186_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969133/SRR9969133.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/098/SRR11396198/SRR11396198_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/004/SRR11396204/SRR11396204.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/032/SRR11396232/SRR11396232.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/015/SRR11396215/SRR11396215.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969201/SRR9969201.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969196/SRR9969196.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/021/SRR11396221/SRR11396221.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/017/SRR11396217/SRR11396217.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969236/SRR9969236_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969113/SRR9969113.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969229/SRR9969229_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/023/SRR11396223/SRR11396223.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/012/SRR11396212/SRR11396212.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969217/SRR9969217_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969182/SRR9969182.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969126/SRR9969126.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/009/SRR11396209/SRR11396209.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969227/SRR9969227_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969176/SRR9969176.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969189/SRR9969189.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969232/SRR9969232_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/030/SRR11396230/SRR11396230.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/007/SRR11396207/SRR11396207.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969222/SRR9969222_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/092/SRR11396192/SRR11396192_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/085/SRR11396185/SRR11396185_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969103/SRR9969103.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/013/SRR11396213/SRR11396213.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969213/SRR9969213_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/008/SRR11396208/SRR11396208.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/097/SRR11396197/SRR11396197_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/083/SRR11396183/SRR11396183_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/094/SRR11396194/SRR11396194_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/089/SRR11396189/SRR11396189.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969166/SRR9969166.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969156/SRR9969156.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/006/SRR11396206/SRR11396206.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/014/SRR11396214/SRR11396214.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/088/SRR11396188/SRR11396188.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969146/SRR9969146.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/022/SRR11396222/SRR11396222.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969241/SRR9969241_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969224/SRR9969224_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969110/SRR9969110.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/049/SRR11396249/SRR11396249.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969204/SRR9969204.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969160/SRR9969160.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969141/SRR9969141.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/095/SRR11396195/SRR11396195_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969122/SRR9969122.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/096/SRR11396196/SRR11396196_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969099/SRR9969099.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969231/SRR9969231_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/031/SRR11396231/SRR11396231.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/057/SRR11396257/SRR11396257.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969191/SRR9969191.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969172/SRR9969172.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969221/SRR9969221_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969233/SRR9969233_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969134/SRR9969134.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969153/SRR9969153.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969209/SRR9969209.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969214/SRR9969214_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969188/SRR9969188.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/040/SRR11396240/SRR11396240.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/048/SRR11396248/SRR11396248.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969211/SRR9969211.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969169/SRR9969169.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969115/SRR9969115.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969240/SRR9969240_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/092/SRR11396192/SRR11396192_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/091/SRR11396191/SRR11396191_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969225/SRR9969225_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969127/SRR9969127.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969230/SRR9969230_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969114/SRR9969114.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/099/SRR11396199/SRR11396199_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969183/SRR9969183.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/039/SRR11396239/SRR11396239.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969219/SRR9969219_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969177/SRR9969177.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/099/SRR11396199/SRR11396199_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969139/SRR9969139.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969145/SRR9969145.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/087/SRR11396187/SRR11396187_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969107/SRR9969107.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969195/SRR9969195.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969200/SRR9969200.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969220/SRR9969220_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969157/SRR9969157.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/081/SRR11396181/SRR11396181_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969234/SRR9969234_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969140/SRR9969140.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/093/SRR11396193/SRR11396193_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/084/SRR11396184/SRR11396184_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969215/SRR9969215_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969119/SRR9969119.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969130/SRR9969130.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969165/SRR9969165.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969102/SRR9969102.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969205/SRR9969205.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969187/SRR9969187.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/038/SRR11396238/SRR11396238.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969241/SRR9969241_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/055/SRR11396255/SRR11396255.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969168/SRR9969168.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969104/SRR9969104.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969222/SRR9969222_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969161/SRR9969161.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969180/SRR9969180.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/084/SRR11396184/SRR11396184_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/081/SRR11396181/SRR11396181_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/046/SRR11396246/SRR11396246.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969203/SRR9969203.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969214/SRR9969214_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969233/SRR9969233_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969135/SRR9969135.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969154/SRR9969154.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969216/SRR9969216_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969144/SRR9969144.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969125/SRR9969125.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/047/SRR11396247/SRR11396247.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969212/SRR9969212.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/000/SRR9969190/SRR9969190.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969227/SRR9969227_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969171/SRR9969171.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969238/SRR9969238_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969178/SRR9969178.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969197/SRR9969197.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/086/SRR11396186/SRR11396186_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/085/SRR11396185/SRR11396185_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/095/SRR11396195/SRR11396195_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/094/SRR11396194/SRR11396194_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/005/SRR9969235/SRR9969235_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969108/SRR9969108.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969223/SRR9969223_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/003/SRR9969213/SRR9969213_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969242/SRR9969242_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969164/SRR9969164.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969101/SRR9969101.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969158/SRR9969158.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/056/SRR11396256/SRR11396256.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969151/SRR9969151.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/002/SRR9969232/SRR9969232_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/007/SRR9969217/SRR9969217_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969206/SRR9969206.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969138/SRR9969138.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969128/SRR9969128.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/058/SRR11396258/SRR11396258.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969131/SRR9969131.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969111/SRR9969111.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR113/059/SRR11396259/SRR11396259.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969226/SRR9969226_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969194/SRR9969194.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/006/SRR9969236/SRR9969236_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/001/SRR9969121/SRR9969121.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/009/SRR9969239/SRR9969239_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/008/SRR9969118/SRR9969118.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR996/004/SRR9969184/SRR9969184.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Bioinformatics, Babraham Institute"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA560249"],"scientific_name":["Mus musculus"],"long_description":["Epigenetic priming factors establish a permissive epigenetic landscape which is not required until a later developmental or physiological time point, temporally uncoupling the presence of these factors with their phenotypic effects. One classic example of epigenetic priming is in the context of bivalent chromatin, found in pluripotent stem cells and early embryos at key developmental gene promoters marked by both activating-associated H3K4me3 and repressive-associated H3K27me3 histone modifications. It is currently unknown how these bivalent domains are targeted, or precisely how they impact on lineage commitment. Here we show that the small heterodimerising non-enzymatic DNA binding proteins Developmental Pluripotency Associated 2 (Dppa2) and 4 (Dppa4) act as epigenetic priming factors to establish bivalency at a subset of developmental genes. Dppa2/4 localise to the +1 nucleosome position of bivalent genes and while they are not required for pluripotency in embryonic stem cells (ESCs), double knockout cells fail to exit pluripotency and to differentiate efficiently, with delays in upregulating bivalently marked lineage genes. Proteomics reveal that Dppa2/4 interact on chromatin with members of the COMPASS and Polycomb complexes important for H3K4me3 and H3K27me3 deposition, respectively. Epigenetic profiling reveals a striking loss of H3K4me3, H3K27me3, and their associated enzymatic machinery at a significant subset of bivalent promoters in Dppa2/4 mutants, in addition to loss of H2A.Z and chromatin accessibility. In wild-type ESCs, these “Dppa2/4-dependent” bivalent promoters are characterised by low H3K4me3 enrichment and breadth, near-absent expression levels and initiating but not elongating RNA polymerase. Notably, Dppa2/4-dependent promoters are less evolutionarily conserved suggesting that they lack additional safeguard measures to maintain bivalency at these genes in the absence of Dppa2/4. Concomitantly with the loss of bivalency, Dppa2/4-dependent bivalent promoters gain DNA methylation and consequently are no longer able to be effectively activated upon ESC differentiation, leading to defects in cell fate acquisition. Our findings reveal a targeting principle for bivalency to developmental gene promoters poising them for future lineage specific gene activation. Overall design: Effects of Dppa2/4 loss on the transcriptome (RNAseq) and epigenome (ChIP-seq, NOME-seq) in mouse embryonic stem cells and differentiating cells"],"tag":["xref:PubMed:32572255"],"repository":["ENA"],"description_synonyms":["2410088E07Rik., PESCRG1, CT100, Epigenetics, D19Mgi18, Epigenetic, C80932, Epigenomic, ECAT15-2"],"name_synonyms":["2410088E07Rik., PESCRG1, CT100, Epigenetics, D19Mgi18, Epigenetic, C80932, Epigenomic, ECAT15-2"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic priming by Dppa2/4 in pluripotency facilitates multi-lineage commitment","description":"Epigenetic priming by Dppa2/4 in pluripotency facilitates multi-lineage commitment","dates":{"last_updated":"2025-09-24","first_public":"2020-06-26"},"accession":"PRJNA560249","cross_references":{"GEO":["GSE135841"],"taxon":["10090"],"PubMed":["32572255"]}}