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Integrative phosphoproteomic screens, RNAseq profiling and follow-up validation studies revealed BRSK2/1-driven activation of AMPK and suppression of MTOR signaling. BRSK2 over-expression suppressed global protein synthesis and decreased ribosome-RNA associations, which results in decreased NRF2 protein levels. Overall, our data establish the BRSK1 and BRSK2 kinases as negative regulators of NRF2 via the AMPK/MTOR signaling axis. Overall design: Evaluation of BRSK2/1 induced changes in RNA via overexpression in HEK293Ts."],"repository":["ENA"],"name_synonyms":["CG13826, RNA polymerase II core promoter proximal region sequence-specific binding, T-cell leukemia, anon-WO0153538.7, anon-WO0153538.6, AGL4, C11orf7, zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, homeobox 1, Factor, SEPALLATA 2, Gm1100, metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity, Transcription Factor, SAD1, l(3)j5E7, l(3)03921, NRF2A, transcription factor activity, BcDNA:RE05559, zinc ion regulated core promoter proximal region sequence-specific DNA binding, E4TF1-60, Dmel_CG13826, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, 4833424K13Rik, CG4566, RNA polymerase II transcription factor activity, NFT2, CG43286, sequence-specific distal enhancer binding RNA polymerase II transcription factor activity, CNC, Cnc, metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, KNOTTED1-like homeobox gene 5, CG17894, DmelCG43286, F14P3.4, hSAD1, Transcription, Factors, copper ion regulated core promoter proximal region sequence-specific binding., F14P3_4, CG4578, F10N7_150, NRF2, CNC_DROME, Nrf2, RCH04A07, metal ion regulated core promoter proximal region sequence-specific binding, SAD-A, SAD-B, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, Transcription factor, F10N7.150, AI194320, 5134, STK29, SADB, RNA polymerase II proximal promoter sequence-specific DNA binding, SADA, copper ion regulated proximal promoter sequence-specific DNA binding, copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, AGAMOUS-like 4, E4TF1A, Dmel_CG17894, zinc ion regulated proximal promoter sequence-specific DNA binding, sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity, metal ion regulated sequence-specific DNA binding, PEN11B, metal ion regulated proximal promoter sequence-specific DNA binding, TRANSCRIPTION FACTOR, RNA polymerase II distal enhancer sequence-specific binding"],"description_synonyms":["CG13826, RNA polymerase II core promoter proximal region sequence-specific binding, T-cell leukemia, anon-WO0153538.7, anon-WO0153538.6, AGL4, C11orf7, zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, homeobox 1, Factor, SEPALLATA 2, Gm1100, metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity, Transcription Factor, SAD1, l(3)j5E7, l(3)03921, NRF2A, transcription factor activity, BcDNA:RE05559, zinc ion regulated core promoter proximal region sequence-specific DNA binding, E4TF1-60, Dmel_CG13826, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, 4833424K13Rik, CG4566, RNA polymerase II transcription factor activity, NFT2, CG43286, sequence-specific distal enhancer binding RNA polymerase II transcription factor activity, CNC, Cnc, metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, KNOTTED1-like homeobox gene 5, CG17894, DmelCG43286, F14P3.4, hSAD1, Transcription, Factors, copper ion regulated core promoter proximal region sequence-specific binding., F14P3_4, CG4578, F10N7_150, NRF2, CNC_DROME, Nrf2, RCH04A07, metal ion regulated core promoter proximal region sequence-specific binding, SAD-A, SAD-B, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, Transcription factor, F10N7.150, AI194320, 5134, STK29, SADB, RNA polymerase II proximal promoter sequence-specific DNA binding, SADA, copper ion regulated proximal promoter sequence-specific DNA binding, copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, AGAMOUS-like 4, E4TF1A, Dmel_CG17894, zinc ion regulated proximal promoter sequence-specific DNA binding, sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity, metal ion regulated sequence-specific DNA binding, PEN11B, metal ion regulated proximal promoter sequence-specific DNA binding, TRANSCRIPTION FACTOR, RNA polymerase II distal enhancer sequence-specific binding"],"additional_accession":[]},"is_claimable":false,"name":"Molecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor","description":"Molecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor","dates":{"last_updated":"2025-09-24","first_public":"2019-11-19"},"accession":"PRJNA578614","cross_references":{"GEO":["GSE139135"],"taxon":["9606"]}}