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The accumulation of these cells depends critically on interleukin (IL)-33 produced by local mesenchymal stromal cells (mSCs). An intriguing physical association between muscle nerves, IL-33+ mSCs and Tregs has been reported, and begs a deeper exploration of this cell triumvirate. Here we evidence a striking proximity between IL-33+ muscle mSCs and both large-fiber nerve bundles and small-fiber sensory neurons report that muscle mSCs transcribe an array of genes encoding neuropeptides, neuropeptide receptors and other nerve-related proteins define muscle mSC subtypes that express both IL-33 and the receptor for the calcitonin-gene-related peptide (CGRP) and demonstrate that up- or down- tuning of CGRP signals augments or diminishes, respectively, IL-33 production by muscle mSCs and later accumulation of muscle Tregs. Indeed, a single injection of CGRP induced much of the genetic program elicited in mSCs early after acute skeletal muscle injury. These findings highlight neural/stromal/immune-cell cross-talk in tissue repair, suggesting future therapeutic approaches. Overall design: Gene expression profiles of muscle mesenchymal stromal cells from mice injected IP with CGRP or PBS (isolated at 4 or 8 hours post-injection). 4 biological replicates were obtained per experimental group."],"tag":["xref:PubMed:32102913"],"repository":["ENA"],"description_synonyms":["3.4.22.-, Multipotent Bone Marrow Stromal Cells, Mesenchymal Stem Cell, Laboratory, Calcium-binding protein in amniotic fluid 1, Mesenchymal Stem Cells, Mus domesticus, Stem Cells, Progenitor Cell, Stromal Cells, Mesenchymal Stromal Cells, Adipose Tissue Derived Mesenchymal Stromal Cell, Wharton's Jelly Cells, mini-ICE, CASP-14, Multipotent Mesenchymal Stromal Cell, House Mouse, Calgranulin-C, CGRP1, bone marrow stromal cells, stem cells, Roles, House, Stromal Cell, Concepts, Mus musculus domesticus, Wharton Jelly Cells, EN-RAGE, mesenchymal precursor cell, Mice, Wharton's Jelly Cell, mesenchymal stromal cell, Multipotent Mesenchymal Stromal Cells, CAAF1, Adipose Tissue-Derived Mesenchymal Stromal Cells, Adipose Derived Mesenchymal Stem Cells, Muscle Tissues, Tissues, Swiss, Tissue, mesenchymal progenitor cells, mesenchymal, Swiss Mice, Bone Marrow Stromal Stem Cells, CAL6, MRP-6, KC, ENRAGE, CFU-F, Cal1, MSC, CA, Bone Marrow Mesenchymal Stem Cells, Calc, Whartons Jelly Cells, Role Concepts, MRP6, marrow stromal cells, CT, Bone Marrow Mesenchymal Stem Cell, Adipose Derived Mesenchymal Stem Cell, Calc1, Adipose-Derived Mesenchymal Stem Cell, Neutrophil S100 protein, Progenitor Cells, Ct, CASP14, mouse, Mesenchymal Progenitor Cells, Muscle, Adipose Tissue-Derived Mesenchymal Stem Cell, Concept, RATCAL6, calcitonin, CGRP-1, CAGC, Mesenchymal Stromal Cell, Role Concept, colony-forming unit-fibroblast, Stem Cell, Mus, Extracellular newly identified RAGE-binding protein, Mini-ICE, Role, CALC1, Mus musculus., CGRP, CGRP-I, S100 calcium-binding protein A12, Mus musculus, Bone Marrow Stromal Cell, Adipose-Derived, BMSC, p6, Adipose-Derived Mesenchymal Stem Cells, mesenchymal stromal cells, Caspase-14 subunit p10, Adipose Tissue Derived Mesenchymal Stromal Cells, mice, Swiss Mouse, Multipotent Bone Marrow Stromal Cell, Adipose Tissue-Derived Mesenchymal Stromal Cell, House Mice, Caspase-14 subunit p19, muscle, Adipose Tissue Derived Mesenchymal Stem Cells, MICE, muscle element, Adipose-Derived Mesenchymal Stromal Cells, Laboratory Mice, domesticus, Adipose Derived, mesenchymal stem cell, Cgrp, Calcitermin, Adipose Tissue-Derived Mesenchymal Stem Cells, Mesenchymal Progenitor Cell, Multipotent, Mesenchymal, Adipose Derived Mesenchymal Stromal Cells, Adipose Tissue Derived Mesenchymal Stem Cell, Migration inhibitory factor-related protein 6, Mouse, Bone Marrow Stromal Cells, Muscle Tissue, Laboratory Mouse, Ctn"],"name_synonyms":["3.4.22.-, Multipotent Bone Marrow Stromal Cells, Mesenchymal Stem Cell, Laboratory, Calcium-binding protein in amniotic fluid 1, Mesenchymal Stem Cells, Mus domesticus, Stem Cells, Progenitor Cell, Stromal Cells, Mesenchymal Stromal Cells, Adipose Tissue Derived Mesenchymal Stromal Cell, Wharton's Jelly Cells, mini-ICE, CASP-14, Multipotent Mesenchymal Stromal Cell, House Mouse, Calgranulin-C, CGRP1, bone marrow stromal cells, stem cells, Roles, House, Stromal Cell, Concepts, Mus musculus domesticus, Wharton Jelly Cells, EN-RAGE, mesenchymal precursor cell, Mice, Wharton's Jelly Cell, mesenchymal stromal cell, Multipotent Mesenchymal Stromal Cells, CAAF1, Adipose Tissue-Derived Mesenchymal Stromal Cells, Adipose Derived Mesenchymal Stem Cells, Muscle Tissues, Tissues, Swiss, Tissue, mesenchymal progenitor cells, mesenchymal, Swiss Mice, Bone Marrow Stromal Stem Cells, CAL6, MRP-6, KC, ENRAGE, CFU-F, Cal1, MSC, CA, Bone Marrow Mesenchymal Stem Cells, Calc, Whartons Jelly Cells, Role Concepts, MRP6, marrow stromal cells, CT, Bone Marrow Mesenchymal Stem Cell, Adipose Derived Mesenchymal Stem Cell, Calc1, Adipose-Derived Mesenchymal Stem Cell, Neutrophil S100 protein, Progenitor Cells, Ct, CASP14, mouse, Mesenchymal Progenitor Cells, Muscle, Adipose Tissue-Derived Mesenchymal Stem Cell, Concept, RATCAL6, calcitonin, CGRP-1, CAGC, Mesenchymal Stromal Cell, Role Concept, colony-forming unit-fibroblast, Stem Cell, Mus, Extracellular newly identified RAGE-binding protein, Mini-ICE, Role, CALC1, Mus musculus., CGRP, CGRP-I, S100 calcium-binding protein A12, Mus musculus, Bone Marrow Stromal Cell, Adipose-Derived, BMSC, p6, Adipose-Derived Mesenchymal Stem Cells, mesenchymal stromal cells, Caspase-14 subunit p10, Adipose Tissue Derived Mesenchymal Stromal Cells, mice, Swiss Mouse, Multipotent Bone Marrow Stromal Cell, Adipose Tissue-Derived Mesenchymal Stromal Cell, House Mice, Caspase-14 subunit p19, muscle, Adipose Tissue Derived Mesenchymal Stem Cells, MICE, muscle element, Adipose-Derived Mesenchymal Stromal Cells, Laboratory Mice, domesticus, Adipose Derived, mesenchymal stem cell, Cgrp, Calcitermin, Adipose Tissue-Derived Mesenchymal Stem Cells, Mesenchymal Progenitor Cell, Multipotent, Mesenchymal, Adipose Derived Mesenchymal Stromal Cells, Adipose Tissue Derived Mesenchymal Stem Cell, Migration inhibitory factor-related protein 6, Mouse, Bone Marrow Stromal Cells, Muscle Tissue, Laboratory Mouse, Ctn"],"additional_accession":[]},"is_claimable":false,"name":"Role of CGRP on muscle mesenchymal stromal cells in mice","description":"Role of CGRP on muscle mesenchymal stromal cells in mice","dates":{"last_updated":"2025-09-24","first_public":"2020-02-12"},"accession":"PRJNA600478","cross_references":{"GEO":["GSE143424"],"taxon":["10090"],"PubMed":["32102913"]}}