ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/015/SRR11059015/SRR11059015.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/082/SRR11058982/SRR11058982.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/004/SRR11059004/SRR11059004.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/088/SRR11058988/SRR11058988.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/094/SRR11058994/SRR11058994.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/099/SRR11058999/SRR11058999.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/081/SRR11058981/SRR11058981.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/009/SRR11059009/SRR11059009.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/092/SRR11058992/SRR11058992.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/086/SRR11058986/SRR11058986.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/011/SRR11059011/SRR11059011.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/014/SRR11059014/SRR11059014.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/003/SRR11059003/SRR11059003.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/097/SRR11058997/SRR11058997.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/017/SRR11059017/SRR11059017.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/006/SRR11059006/SRR11059006.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/010/SRR11059010/SRR11059010.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/093/SRR11058993/SRR11058993.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/089/SRR11058989/SRR11058989.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/001/SRR11059001/SRR11059001.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/085/SRR11058985/SRR11058985.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/096/SRR11058996/SRR11058996.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/013/SRR11059013/SRR11059013.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/002/SRR11059002/SRR11059002.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/090/SRR11058990/SRR11058990.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/018/SRR11059018/SRR11059018.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/007/SRR11059007/SRR11059007.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/000/SRR11059000/SRR11059000.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/005/SRR11059005/SRR11059005.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/016/SRR11059016/SRR11059016.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/083/SRR11058983/SRR11058983.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/084/SRR11058984/SRR11058984.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/098/SRR11058998/SRR11058998.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/095/SRR11058995/SRR11058995.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/091/SRR11058991/SRR11058991.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/087/SRR11058987/SRR11058987.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/012/SRR11059012/SRR11059012.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR110/008/SRR11059008/SRR11059008.fastq.gzprimaryOK200GenomicsGenomics Core, Developmental and Cognitive Neuroscience, Yerkes National Primate Research Centerhttps://www.ebi.ac.uk/ena/browser/view/PRJNA605839Mus musculusTo identify brain region specific proteins that contribute to brain region specific neurodegeneration, RNA sequencing was performed using cerebellum, striatum and prefrontal cortex tissues from 3-month-old SCA17 knock-in (KI) mice and wild-type (WT) littermates. We find 245 cerebellar specifically dysregulated genes (110 up-regulated genes and 145 down-regulated genes), 133 striatum specifically dysregulated genes (45 up-regulated genes and 88 down-regulated genes) and 17 prefrontal cortex specifically dysregulated genes (4 up-regulated genes and 13 down-regulated genes). Combined with other evidences, we demonstrate that cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of Spinocerebellar ataxias type 17 Overall design: To compare RNA level of cerebellum, striatum and prefrontal cortex from 3-month old WT and KI mice of SCA-17 by RNA sequencing, each group consists three mice.xref:PubMed:32107387ENAthe brain, Mus musculus, 3.4.22.-, GTF2D, HDL4, suprasegmental structures, Caspase-14 subunit p10, Laboratory, Swiss, mice, Mus domesticus, mouse, Swiss Mouse, House Mice, Swiss Mice, mini-ICE, Caspase-14 subunit p19, CASP-14, suprasegmental levels of nervous system, MICE, House Mouse, encephalon, Encephalon., Laboratory Mice, domesticus, olivopontocerebellar atrophy V, SCA17, House, Mus, late-onset recessive type, GTF2D1, Mini-ICE, Mus musculus domesticus, TFIID, Mouse, synganglion, Gtf2d, CPD, Mice, Laboratory Mousethe brain, Mus musculus, 3.4.22.-, GTF2D, HDL4, suprasegmental structures, Caspase-14 subunit p10, Laboratory, Swiss, mice, Mus domesticus, mouse, Swiss Mouse, House Mice, Swiss Mice, mini-ICE, Caspase-14 subunit p19, CASP-14, suprasegmental levels of nervous system, MICE, House Mouse, encephalon, Encephalon., Laboratory Mice, domesticus, olivopontocerebellar atrophy V, SCA17, House, Mus, late-onset recessive type, GTF2D1, Mini-ICE, Mus musculus domesticus, TFIID, Mouse, synganglion, Gtf2d, CPD, Mice, Laboratory MousefalseSCA17 knock-in mice brain transcriptomesSCA17 knock-in mice brain transcriptomes2025-09-242020-02-12PRJNA605839GSE1450671009032107387