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Then the macrophages were treated with a PXR ligand PCN or DMSO control for 12 hr. Total RNA was extracted for RNAseq Results: PCN-mediated PXR activation induced 439 differentially expressed genes (DEGs) with false discovery rate (FDR) 1.5 in control macrophages. By contrast, PCN only induced 38 DEFs in PXR-deficient macrophages. Conclusions: These results indicate that PXR signaling may affect many genes in macrophages related atherosclerosis development. Overall design: Macrophagic mRNA profiles of control and PXR-deficient macrophages after 12-hr treatment of PXR ligand PCN"],"tag":["xref:PubMed:32170024"],"repository":["ENA"],"description_synonyms":["PAR, macrophagocyte, PXR1, Transcriptome, Monocyte Derived Macrophages, Transcriptome Profile, SXR, typical plasmatocyte, mPXR, Expression Profiles, PRR, Gene Expression Profile, Gene, Monocyte Derived, Profiles, monocyte-derived macrophage, ONR1, PXR.1, PXR.2, Gene Expression, Monocyte-Derived, macrophage, Transcriptome Profiles., Expression Signatures, Gene Expression Signatures, Monocyte-Derived Macrophage, PARq, Gene Expression Signature, agranular plasmatocyte, Expression Profile, activation, BXR, Monocyte-Derived Macrophages, Macrophage, SAR, PXR, Macrophages, Profile, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, Signatures, Bone Marrow-Derived, lamellocyte, Expression Signature, Gene Expression Profiles, Bone Marrow-Derived Macrophages, granulocyte, Transcriptomes, PAR2, PAR1, histiocyte, Signature"],"name_synonyms":["PAR, macrophagocyte, PXR1, Transcriptome, Monocyte Derived Macrophages, Transcriptome Profile, SXR, typical plasmatocyte, mPXR, Expression Profiles, PRR, Gene Expression Profile, Gene, Monocyte Derived, Profiles, monocyte-derived macrophage, ONR1, PXR.1, PXR.2, Gene Expression, Monocyte-Derived, macrophage, Transcriptome Profiles., Expression Signatures, Gene Expression Signatures, Monocyte-Derived Macrophage, PARq, Gene Expression Signature, agranular plasmatocyte, Expression Profile, activation, BXR, Monocyte-Derived Macrophages, Macrophage, SAR, PXR, Macrophages, Profile, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, Signatures, Bone Marrow-Derived, lamellocyte, Expression Signature, Gene Expression Profiles, Bone Marrow-Derived Macrophages, granulocyte, Transcriptomes, PAR2, PAR1, histiocyte, Signature"],"additional_accession":[]},"is_claimable":false,"name":"Effects of PXR activation on the macrophage transcriptome","description":"Effects of PXR activation on the macrophage transcriptome","dates":{"last_updated":"2025-09-24","first_public":"2020-02-23"},"accession":"PRJNA607989","cross_references":{"GEO":["GSE145719"],"taxon":["10090"],"PubMed":["32170024"]}}