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Then the macrophages were treated with a PXR ligand PCN or DMSO control for 12 hr. Total RNA was extracted for RNAseq Results: PCN-mediated PXR activation induced 439 differentially expressed genes (DEGs) with false discovery rate (FDR) 1.5 in control macrophages. By contrast, PCN only induced 38 DEFs in PXR-deficient macrophages. Conclusions: These results indicate that PXR signaling may affect many genes in macrophages related atherosclerosis development. Overall design: Macrophagic mRNA profiles of control and PXR-deficient macrophages after 12-hr treatment of PXR ligand PCNxref:PubMed:32170024ENAPAR, macrophagocyte, PXR1, Transcriptome, Monocyte Derived Macrophages, Transcriptome Profile, SXR, typical plasmatocyte, mPXR, Expression Profiles, PRR, Gene Expression Profile, Gene, Monocyte Derived, Profiles, monocyte-derived macrophage, ONR1, PXR.1, PXR.2, Gene Expression, Monocyte-Derived, macrophage, Transcriptome Profiles., Expression Signatures, Gene Expression Signatures, Monocyte-Derived Macrophage, PARq, Gene Expression Signature, agranular plasmatocyte, Expression Profile, activation, BXR, Monocyte-Derived Macrophages, Macrophage, SAR, PXR, Macrophages, Profile, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, Signatures, Bone Marrow-Derived, lamellocyte, Expression Signature, Gene Expression Profiles, Bone Marrow-Derived Macrophages, granulocyte, Transcriptomes, PAR2, PAR1, histiocyte, SignaturePAR, macrophagocyte, PXR1, Transcriptome, Monocyte Derived Macrophages, Transcriptome Profile, SXR, typical plasmatocyte, mPXR, Expression Profiles, PRR, Gene Expression Profile, Gene, Monocyte Derived, Profiles, monocyte-derived macrophage, ONR1, PXR.1, PXR.2, Gene Expression, Monocyte-Derived, macrophage, Transcriptome Profiles., Expression Signatures, Gene Expression Signatures, Monocyte-Derived Macrophage, PARq, Gene Expression Signature, agranular plasmatocyte, Expression Profile, activation, BXR, Monocyte-Derived Macrophages, Macrophage, SAR, PXR, Macrophages, Profile, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophage, Signatures, Bone Marrow-Derived, lamellocyte, Expression Signature, Gene Expression Profiles, Bone Marrow-Derived Macrophages, granulocyte, Transcriptomes, PAR2, PAR1, histiocyte, SignaturefalseEffects of PXR activation on the macrophage transcriptomeEffects of PXR activation on the macrophage transcriptome2025-09-242020-02-23PRJNA607989GSE1457191009032170024