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of Subtropical Agriculture, Chinese Academy of Scienceshttps://www.ebi.ac.uk/ena/browser/view/PRJNA609407Synbiotic ingestion could improve the gut microbiota balance which is associated with the reproductive performance and their metabolism in sows. The present study was conducted to determine the effects of dietary synbiotic supplementation on reproductive performance, plasma biochemical parameters, and fecal microbiome composition and metabolite levels in pregnant and lactating sows. Compared to the control group, synbiotic supplementation increased the piglet survival rate and decreased colostrum somatic cell number synbiotic or antibiotic supplementation improved plasma lipid metabolism. Synbiotic supplementation increased the fecal Simpson and Shannon indices, and Coprococcus, Clostridium, and Ruminococcus abundance on day 105 of pregnancy, while decreased Desulfovibrio and Herbaspirillum abundance on day 21 of lactation as compared to that in the other two groups. Spearman analysis showed a positive correlation between Ruminococcus abundance and bioamine level on day 105 of pregnancy but a negative correlation between Desulfovibrio abundance and butyrate level on day 21 of lactation. These findings suggest that dietary synbiotic supplementation has improved reproductive performance and lipid/nitrogen metabolism by altering gut microbiota composition and abundance in pregnant and lactating sows.ENAPlasma, Fresh, Fresh Frozen Plasmas, Fresh Frozen, Microbial Community Composition, portion of blood plasma, Blood Plasma, Community Composition, Frozen Plasma, Microbiomes, Fresh Frozen Plasma, Microbial Community Compositions, Microbial Community, gravid, Dietary, Blood, Microbial Community Structure, Community Structure, portion of plasma, Microbial, pregnant adult, Plasmas, metabolite levels, Human, Frozen Plasmas, Composition, metabolite traits, blood plasm, Synbiotic, Blood Plasmas, Diets, Microbial Community Structures, Microbiotas, pregnant., plasma, Human Microbiomes, Microbial Communities, Community, Human Microbiome, MicrobiomefalseDietary Synbiotic Supplementation Alters Reproductive Performance, Plasma Biochemical Parameters, Fecal Microbiota Composition, and Metabolite Levels in Pregnant and Lactating Sows2023-05-192020-06-30PRJNA609407