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112/080/SRR11291080/SRR11291080_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR112/087/SRR11291087/SRR11291087_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR112/051/SRR11263451/SRR11263451.fastq.gzprimaryOK200GenomicsUniversity of Zurichhttps://www.ebi.ac.uk/ena/browser/view/PRJNA610985Homo sapiensxref:EuropePMC:PMC8102911Trans-differentiation is the conversion of a differentiated somatic cell type into another one without de-differentiation and re-acquisition of the pluripotent state. Several studies suggested a role of ADP-ribosylation in regulating chromatin changes associated with differentiation and de-differentiation processes, but the role of ADP-ribosylation in cell-type conversion is unknown.MyoD is a master transcription factor, whose expression is sufficient to trans-differentiate fibroblasts to myoblasts. We observed a MyoD-dependent enhanced expression of ARTD1 that co-regulated only a subset of MyoD target genes in fibroblast-derived myoblasts. Comprehensive analysis of the genome organization by Hi-C analysis suggested that ARTD1 and ARTD1-dependent ADP-ribosylation might contribute to A/B compartmentalization in IMR90 cells, but not in a MyoD-dependent manner. The induction of ARTD1 was accompanied by the synthesis of nuclear ADP-ribosylation that was neither dependent on the cell cycle nor on DNA damage or transcriptional elongation. However, MyoD-induced trans-differentiation increased the DNA damage response induced by etoposide. Together, these data provide further insights into the molecular mechanisms associated with cell type conversion and nuclear ADP-ribosylation.ENAHuman, Modern., human being, Man (Taxonomy), Homo sapiens, man, Man, human, Modern Manpoly(ADP-ribose) polymerase 1, ADPRibosylation, NAU, Nau, F16D14.16, DmelCG40411, bHLHc1, MARylation, Embryonic Muscle Cells, ADP, Precursor, LD21673.3prime, Mdrf, Mono(ADP-Ribosyl)ation, pADPRT-1, BEST:LD21673, Ribosylation, F16D14_16, ATPARP1, Ribosylations, Adprt1, PARP1, MyoD, MYOD, (ADP-Ribosyl)ation, Embryonic., Mono, CG40411, MARylations, sPARP-1, Embryonic Muscle Cell, NAD(+) ADP-ribosyltransferase 1, Mono ADPRibosylations, Mono ADP Ribosylation, MonoADPRibosylations, Myoblast, ADP-ribosyltransferase diphtheria toxin-like 1, C80510, ADPRT, Muscle Cell, CG17696, Mono(ADPRibosyl)ation, (ADPRibosyl)ation, AI503393, Embryonic, Precursor Muscle Cell, Mono ADPRibosylation, Myod-1, Adprp, ARTD1, PARP, ADPRT1, Adprt, AI893648, ADP-Ribosylations, ADPRibosylations, Dmyd, ADP Ribosylation, CG10250, Poly[ADP-ribose] synthase 1, adprt1, Muscle Cells, parp, CG17685, Mono-ADP-Ribosylations, Mono-ADPRibosylations, CG17718, Parp-1, MonoADPRibosylation, Mono-ADP-Ribosylation, ADP Ribosylations, padprt-1, PUM, ppol, DmelCG10250, ADPRT 1, PARP-1, D.PARP, msPARP, dPARP, Precursor Muscle Cells, Dm.pARTa, PPOL, 5830444G22Rik, parp-1, 2.4.2.30, MYF3, Fibroblast, Mono-ADPRibosylationfalseHomo sapiensMyoD induces ARTD1-dependent nuclear ADP-ribosylation during fibroblasts to myoblasts trans-differentiation2025-09-242020-10-01PRJNA6109859606