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To do so, we performed an unbiased screening using RNAsequing. With this technique, we identified, in two human breast cancer metastatic cell lines (MDA-MB-231 and SKBR3), 13 commonly significant modulated genes that are involved in metabolic switches. Five of these genes were confirmed by RT-qPCR, and four were proved at protein level. In vivo experiments using an orthotopic model of the highly metastatic cell line MDA-MB-231 further demonstrated that modulation of some of the target genes can be observed in mice without tumor recurrence and without lung micrometastasis. Together, our results identified members of signaling pathways induced by mtROS in human metastatic breast cancer cells, and demonstrated that targeting mtROS in metastatic breast cancer can impair their invasive phenotype. Overall design: Examination of gene expression modulations upon MitoQ treatment in 2 breast cancer cell lines"],"repository":["ENA"],"description_synonyms":["Biological Markers, Viral Marker, Viral, human being, Surrogate Endpoints, Surrogate Endpoint, Clinical Markers, Laboratory, Clinical Marker, Modern, Serum Markers, Biochemical, Cell Lines, End Point, Endpoint, Biochemical Markers, Serum, Biologic Marker, Cell, Immune Marker, Surrogate End Points, Human, Surrogate Markers, Laboratory Markers, Homo sapiens, Marker, Biological, Surrogate End Point, Line, Cell., Man, Biologic Markers, Lines, Biomarker, Serum Marker, Clinical, Man (Taxonomy), End Points, Surrogate, Biological Marker, Endpoints, Immunologic, Laboratory Marker, Surrogate Marker, human, Immunologic Markers, Immune, Markers, Biochemical Marker, Viral Markers, Modern Man, Immunologic Marker, Biologic, Immune Markers"],"name_synonyms":["Biological Markers, Viral Marker, Viral, human being, Surrogate Endpoints, Surrogate Endpoint, Clinical Markers, Laboratory, Clinical Marker, Modern, Serum Markers, Biochemical, Cell Lines, End Point, Endpoint, Biochemical Markers, Serum, Biologic Marker, Cell, Immune Marker, Surrogate End Points, Human, Surrogate Markers, Laboratory Markers, Homo sapiens, Marker, Biological, Surrogate End Point, Line, Cell., Man, Biologic Markers, Lines, Biomarker, Serum Marker, Clinical, Man (Taxonomy), End Points, Surrogate, Biological Marker, Endpoints, Immunologic, Laboratory Marker, Surrogate Marker, human, Immunologic Markers, Immune, Markers, Biochemical Marker, Viral Markers, Modern Man, Immunologic Marker, Biologic, Immune Markers"],"additional_accession":[]},"is_claimable":false,"name":"Search for biomarkers of response to MitoQ in human breast cancer cell lines","description":"Search for biomarkers of response to MitoQ in human breast cancer cell lines","dates":{"last_updated":"2025-09-24","first_public":"2020-04-17"},"accession":"PRJNA623273","cross_references":{"GEO":["GSE148111"],"taxon":["9606"]}}