{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR114/089/SRR11488789/SRR11488789.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR114/085/SRR11488785/SRR11488785.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR114/086/SRR11488786/SRR11488786.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR114/088/SRR11488788/SRR11488788.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR114/087/SRR11488787/SRR11488787.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR114/083/SRR11488783/SRR11488783.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR114/084/SRR11488784/SRR11488784.fastq.gz"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Warnatz Lab, Department of Rheumatology and clinical immunology, University Medical Center Freiburg"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA623360"],"scientific_name":["Homo sapiens"],"long_description":["A subgroup of CVID patients presents with a loss of switched memory B cells and an accumulation of CD21low B cells.RNAseq data from CVID derived CD21low and CD21pos B cells were compared to naive CD21pos B cells in Healthy controls. The data reveal a distinct gene expression profile in CD21low B cells compared to HD. Overall design: CD21 low and CD21pos B cells were sorted from freshly isolated PBMCs of CVID patients and healthy controls. Sorting included gating on CD19pos, CD27neg, IgDpos naive B cells and CD21low and CD21pos B cells were differentiated by low expression of CD21 and CD38 or high expression of CD21 and intermediate to low levels of CD38 respectively and cells were processed for RNA isolation."],"tag":["xref:PubMed:34623902","xref:PubMed:40013136"],"repository":["ENA"],"description_synonyms":["hypogamma-globulinemia, Late-Onset Immunoglobulin Deficiency, Hypogammaglobulinemia, COMMON VARIABL IMMUNODEF, Deficiencies, Gene, Common variable agammaglobulinaemia, Immunoglobulin Deficiencies, Common variable agammaglobulinemia, Cell, RYZN, acquired, Common variable agammaglobulinemia (disorder), Common Variable Hypogammaglobulinemias, Variable Hypogammaglobulinemia, Sporadic hypogammaglobulinemia, common variable hypogamma-globulinemia, Late-Onset Immunoglobulin Deficiencies, Immunodeficiency, Client., IMMUNODEFIC COMMON VARIABLE, Acquired Agammaglobulinemia, common variable immunodeficiency, Immunodeficiencies, Common, CVI - Common variable immunodeficiency, Variable Hypogammaglobulinemias, TACI, IGAD2, Common Variable, CVID - Common variable immunodeficiency, Hypogammaglobulinemias, CD267, Acquired Hypogammaglobulinemias, acquired hypogammaglobulinemia, Acquired, CVAG, Gene Expressions, acquired agammaglobulinemia, Late-Onset, Immunoglobulin deficiency, Common variable hypogammaglobulinaemia, CVID, Common Variable Hypogammaglobulinemia, Expressions, late-onset, Common variable hypogammaglobulinemia, acquired Agammaglobulinemia, TNFRSF14B, common variable immune deficiency, Deficiency, Late Onset, Patient, Clients, Common Variable Immunodeficiencies, Immunoglobulin Deficiency, COMMON VARIABLE IMMUNODEFIC, Late onset immunoglobulin deficiency, Expression, Late-Onset Immunoglobulin, Acquired hypogammaglobulinaemia, CVID2"],"name_synonyms":["hypogamma-globulinemia, Late-Onset Immunoglobulin Deficiency, Hypogammaglobulinemia, COMMON VARIABL IMMUNODEF, Deficiencies, Gene, Common variable agammaglobulinaemia, Immunoglobulin Deficiencies, Common variable agammaglobulinemia, Cell, RYZN, acquired, Common variable agammaglobulinemia (disorder), Common Variable Hypogammaglobulinemias, Variable Hypogammaglobulinemia, Sporadic hypogammaglobulinemia, common variable hypogamma-globulinemia, Late-Onset Immunoglobulin Deficiencies, Immunodeficiency, Client., IMMUNODEFIC COMMON VARIABLE, Acquired Agammaglobulinemia, common variable immunodeficiency, Immunodeficiencies, Common, CVI - Common variable immunodeficiency, Variable Hypogammaglobulinemias, TACI, IGAD2, Common Variable, CVID - Common variable immunodeficiency, Hypogammaglobulinemias, CD267, Acquired Hypogammaglobulinemias, acquired hypogammaglobulinemia, Acquired, CVAG, Gene Expressions, acquired agammaglobulinemia, Late-Onset, Immunoglobulin deficiency, Common variable hypogammaglobulinaemia, CVID, Common Variable Hypogammaglobulinemia, Expressions, late-onset, Common variable hypogammaglobulinemia, acquired Agammaglobulinemia, TNFRSF14B, common variable immune deficiency, Deficiency, Late Onset, Patient, Clients, Common Variable Immunodeficiencies, Immunoglobulin Deficiency, COMMON VARIABLE IMMUNODEFIC, Late onset immunoglobulin deficiency, Expression, Late-Onset Immunoglobulin, Acquired hypogammaglobulinaemia, CVID2"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression in CD21low and CD21pos B cells from CVID patients","description":"Gene expression in CD21low and CD21pos B cells from CVID patients","dates":{"last_updated":"2025-09-24","first_public":"2020-05-06"},"accession":"PRJNA623360","cross_references":{"GEO":["GSE148163"],"taxon":["9606"],"PubMed":["40013136","34623902"]}}