ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/053/SRR11743953/SRR11743953.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/052/SRR11743952/SRR11743952.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/050/SRR11743950/SRR11743950.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/051/SRR11743951/SRR11743951.fastq.gzprimary200OKGenomicsBuchmann Institute for Molecular Life Sciences (BMLS), Goethe University Frankfurthttps://www.ebi.ac.uk/ena/browser/view/PRJNA631368Homo sapiensxref:PubMed:33376132The downregulation of diabetes susceptibility gene GLIS3 contributes to pancreatic beta cell demise, at least in part, through downregulation of the splicing factor SRSF6. Here, we used individual-nucleotide UV crosslinking and immunoprecipitation (iCLIP) to map the RNA binding landscape of SRSF6 in pancreatic beta cells. Overall design: Four independent iCLIP replicates for endogeneous SRSF6 from human pancreatic beta cells (EndoC-βH1 cell line)ENAModb1, Regulations, Sfrs6, nuclear mRNA cis splicing, Materials, MUTYH-Associated Polyposis, SRP55, DM, methionine aminopeptidase activity, Social Controls., Formal Social Control, MYH-associated polyposis, autosomal recessive familial adenomatous polyposis, Maps, Gene, Ximpact, Cistrons, impact-a, diabetes mellitus (disease), OB-RGRP, Social Control, Diabetes mellitus (disorder), 2, IMPACT, imprinted and ancient gene protein homolog, Genetic Materials, NOS, Leprb, Formal Social Controls, familial adenomatous polyposis, Genetic Material, MAP, peptidase M activity, autosomal recessive, DM - Diabetes mellitus, adenomas, imprinted and ancient gene protein, LEPROT, HEL-S-91, RUTBC3, rabGAPLP, susceptibility, L-methionine aminopeptidase activity, Genetic, diabetes mellitus, familial adenomatous polyposis 2, AI314910, SFRS6, Control, RabGAP-5, obese-like, 1210001E11Rik, MYH-Associated Polyposis, Controls, Obr, B52, RABGAP5, Diabetes NOS, autosomal recessive multiple colorectal adenomas, Social, via U2-type spliceosome, AW146126, Diabetes mellitus, Material, RUSC3, multiple colorectal, MAP syndrome, Cistron, regulation, obl, E430016J11Rik, Regulation, Diabetes, RWDD5, FAP2, diabetes, db, colorectal adenomatous polyposisModb1, Regulations, Sfrs6, nuclear mRNA cis splicing, Materials, MUTYH-Associated Polyposis, SRP55, DM, methionine aminopeptidase activity, Social Controls., Formal Social Control, MYH-associated polyposis, autosomal recessive familial adenomatous polyposis, Maps, Gene, Ximpact, Cistrons, impact-a, diabetes mellitus (disease), OB-RGRP, Social Control, Diabetes mellitus (disorder), 2, IMPACT, imprinted and ancient gene protein homolog, Genetic Materials, NOS, Leprb, Formal Social Controls, familial adenomatous polyposis, Genetic Material, MAP, peptidase M activity, autosomal recessive, DM - Diabetes mellitus, adenomas, imprinted and ancient gene protein, LEPROT, HEL-S-91, RUTBC3, rabGAPLP, susceptibility, L-methionine aminopeptidase activity, Genetic, diabetes mellitus, familial adenomatous polyposis 2, AI314910, SFRS6, Control, RabGAP-5, obese-like, 1210001E11Rik, MYH-Associated Polyposis, Controls, Obr, B52, RABGAP5, Diabetes NOS, autosomal recessive multiple colorectal adenomas, Social, via U2-type spliceosome, AW146126, Diabetes mellitus, Material, RUSC3, multiple colorectal, MAP syndrome, Cistron, regulation, obl, E430016J11Rik, Regulation, Diabetes, RWDD5, FAP2, diabetes, db, colorectal adenomatous polyposisfalseIdentification of SRSF6 splicing regulatory map and its impact on diabetes susceptibility genes regulationIdentification of SRSF6 splicing regulatory map and its impact on diabetes susceptibility genes regulation2025-09-242020-12-24PRJNA631368GSE150172960633376132