ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/050/SRR11788850/SRR11788850_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/058/SRR11788858/SRR11788858_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/054/SRR11788854/SRR11788854_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/056/SRR11788856/SRR11788856_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/048/SRR11788848/SRR11788848_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/054/SRR11788854/SRR11788854_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/050/SRR11788850/SRR11788850_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/055/SRR11788855/SRR11788855_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/049/SRR11788849/SRR11788849_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/056/SRR11788856/SRR11788856_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/058/SRR11788858/SRR11788858_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/053/SRR11788853/SRR11788853_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/052/SRR11788852/SRR11788852_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/059/SRR11788859/SRR11788859_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/051/SRR11788851/SRR11788851_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/049/SRR11788849/SRR11788849_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/057/SRR11788857/SRR11788857_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/053/SRR11788853/SRR11788853_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/059/SRR11788859/SRR11788859_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/051/SRR11788851/SRR11788851_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/052/SRR11788852/SRR11788852_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/055/SRR11788855/SRR11788855_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/057/SRR11788857/SRR11788857_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR117/048/SRR11788848/SRR11788848_2.fastq.gzprimary200OKGenomicsGuangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Biochemistry and Molecular Biology, South China Normal Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA632745Mus musculusN6-Methyladenosine (m6A) modification has been found to play important roles in diverse pathogen infections and host responses, here we report host m6A mRNA transcriptome profiles regulated by the infections of two strains of malaria parasite Plasmodium yoelii (N67 and N67C). We showed that malaria infection can regulate host m6A mRNA modification and reprogram host m6A mRNA methylome by mediating corresponding m6A catalytic enzyme levels. Our data suggested m6A modification as a significant transcriptome-wide mark during host-malaria interactions. Overall design: m6A mRNA modifications were profiled in mice infected with two strains of malaria parasite Plasmodium yoelii (N67 and N67C) compared to noninfection controlxref:PubMed:36203583ENARegulations, host organism, Transcriptome, wide/broad, Transcriptome Profile, Formal Social Control, Expression Profiles, N6-methyladenosine (m6A), IME4, Plasmodium, Gene Expression Profile, GPM6, Gpm6, Remittent, Infestations and Infections, Gene, Profiles, broad, Social Controls, m(6)A, whole transcriptome, Gene Expression, Plasmodium Infections, Social Control, Expression Signatures, Gene Expression Signatures, MT-A70, Infection, Gene Expression Signature, clinical infection., Expression Profile, N6-methyladenosine, Formal Social Controls, Transcriptome Profiles, Spo8, Plasmodium Infection, Infections, Profile, Control, Infection and Infestation, Controls, M6A, Signatures, 6-methyladenosine, Social, N(6)mAdo, 2310024F18Rik, Infestation and Infection, wide, Parasite, N(6)-methyladenosine, Expression Signature, Gene Expression Profiles, Fever, Transcriptomes, Remittent Fever, regulation, Infections and Infestations, Signature, M6a, m6A, Marsh, Regulation, plasmodiosis, Marsh Fever, PaludismRegulations, host organism, Transcriptome, wide/broad, Transcriptome Profile, Formal Social Control, Expression Profiles, N6-methyladenosine (m6A), IME4, Plasmodium, Gene Expression Profile, GPM6, Gpm6, Remittent, Infestations and Infections, Gene, Profiles, broad, Social Controls, m(6)A, whole transcriptome, Gene Expression, Plasmodium Infections, Social Control, Expression Signatures, Gene Expression Signatures, MT-A70, Infection, Gene Expression Signature, clinical infection., Expression Profile, N6-methyladenosine, Formal Social Controls, Transcriptome Profiles, Spo8, Plasmodium Infection, Infections, Profile, Control, Infection and Infestation, Controls, M6A, Signatures, 6-methyladenosine, Social, N(6)mAdo, 2310024F18Rik, Infestation and Infection, wide, Parasite, N(6)-methyladenosine, Expression Signature, Gene Expression Profiles, Fever, Transcriptomes, Remittent Fever, regulation, Infections and Infestations, Signature, M6a, m6A, Marsh, Regulation, plasmodiosis, Marsh Fever, PaludismfalseTranscriptome-wide regulation of host m6A mRNA methylation by malaria parasite infectionTranscriptome-wide regulation of host m6A mRNA methylation by malaria parasite infection2025-09-242021-05-26PRJNA632745GSE1505461009036203583