ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/051/SRR12079751/SRR12079751_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/047/SRR12079747/SRR12079747_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/023/SRR12079723/SRR12079723_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/075/SRR12079775/SRR12079775_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/074/SRR12079774/SRR12079774_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/092/SRR12079792/SRR12079792_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/050/SRR12079750/SRR12079750_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/088/SRR12079788/SRR12079788_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/029/SRR12079729/SRR12079729_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/034/SRR12079734/SRR12079734_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/064/SRR12079764/SRR12079764_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/059/SRR12079759/SRR12079759_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/058/SRR12079758/SRR12079758_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/057/SRR12079757/SRR12079757_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/040/SRR12079740/SRR12079740_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/033/SRR12079733/SRR12079733_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/081/SRR12079781/SRR12079781_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/099/SRR12079799/SRR12079799_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/098/SRR12079798/SRR12079798_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/090/SRR12079790/SRR12079790_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/053/SRR12079753/SRR12079753_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/076/SRR12079776/SRR12079776_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/031/SRR12079731/SRR12079731_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/085/SRR12079785/SRR12079785_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/038/SRR12079738/SRR12079738_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/079/SRR12079779/SRR12079779_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/091/SRR12079791/SRR12079791_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/032/SRR12079732/SRR12079732_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/086/SRR12079786/SRR12079786_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/037/SRR12079737/SRR12079737_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/052/SRR12079752/SRR12079752_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/070/SRR12079770/SRR12079770_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/046/SRR12079746/SRR12079746_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/077/SRR12079777/SRR12079777_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/056/SRR12079756/SRR12079756_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/061/SRR12079761/SRR12079761_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/055/SRR12079755/SRR12079755_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/062/SRR12079762/SRR12079762_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/078/SRR12079778/SRR12079778_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/039/SRR12079739/SRR12079739_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/027/SRR12079727/SRR12079727_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/071/SRR12079771/SRR12079771_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/066/SRR12079766/SRR12079766_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/025/SRR12079725/SRR12079725_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/054/SRR12079754/SRR12079754_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/083/SRR12079783/SRR12079783_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/095/SRR12079795/SRR12079795_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/030/SRR12079730/SRR12079730_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/042/SRR12079742/SRR12079742_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/081/SRR12079781/SRR12079781_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/060/SRR12079760/SRR12079760_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/054/SRR12079754/SRR12079754_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/072/SRR12079772/SRR12079772_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/066/SRR12079766/SRR12079766_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/042/SRR12079742/SRR12079742_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/078/SRR12079778/SRR12079778_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/039/SRR12079739/SRR12079739_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/036/SRR12079736/SRR12079736_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/084/SRR12079784/SRR12079784_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/024/SRR12079724/SRR12079724_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/030/SRR12079730/SRR12079730_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/096/SRR12079796/SRR12079796_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/027/SRR12079727/SRR12079727_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/045/SRR12079745/SRR12079745_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/084/SRR12079784/SRR12079784_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/096/SRR12079796/SRR12079796_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/057/SRR12079757/SRR12079757_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/069/SRR12079769/SRR12079769_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/048/SRR12079748/SRR12079748_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/051/SRR12079751/SRR12079751_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/060/SRR12079760/SRR12079760_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/063/SRR12079763/SRR12079763_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/072/SRR12079772/SRR12079772_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/033/SRR12079733/SRR12079733_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/075/SRR12079775/SRR12079775_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/087/SRR12079787/SRR12079787_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/036/SRR12079736/SRR12079736_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/000/SRR12079800/SRR12079800_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/093/SRR12079793/SRR12079793_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/099/SRR12079799/SRR12079799_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/024/SRR12079724/SRR12079724_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/090/SRR12079790/SRR12079790_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/086/SRR12079786/SRR12079786_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/063/SRR12079763/SRR12079763_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/062/SRR12079762/SRR12079762_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/035/SRR12079735/SRR12079735_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/091/SRR12079791/SRR12079791_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/048/SRR12079748/SRR12079748_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/076/SRR12079776/SRR12079776_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/052/SRR12079752/SRR12079752_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/046/SRR12079746/SRR12079746_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/069/SRR12079769/SRR12079769_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/093/SRR12079793/SRR12079793_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/045/SRR12079745/SRR12079745_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/087/SRR12079787/SRR12079787_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/029/SRR12079729/SRR12079729_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/041/SRR12079741/SRR12079741_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/098/SRR12079798/SRR12079798_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/088/SRR12079788/SRR12079788_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/028/SRR12079728/SRR12079728_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/000/SRR12079800/SRR12079800_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/044/SRR12079744/SRR12079744_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/050/SRR12079750/SRR12079750_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/073/SRR12079773/SRR12079773_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/080/SRR12079780/SRR12079780_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/097/SRR12079797/SRR12079797_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/026/SRR12079726/SRR12079726_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/089/SRR12079789/SRR12079789_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/034/SRR12079734/SRR12079734_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/040/SRR12079740/SRR12079740_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/049/SRR12079749/SRR12079749_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/043/SRR12079743/SRR12079743_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/074/SRR12079774/SRR12079774_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/065/SRR12079765/SRR12079765_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/064/SRR12079764/SRR12079764_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/059/SRR12079759/SRR12079759_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/058/SRR12079758/SRR12079758_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/067/SRR12079767/SRR12079767_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/068/SRR12079768/SRR12079768_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/043/SRR12079743/SRR12079743_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/094/SRR12079794/SRR12079794_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/055/SRR12079755/SRR12079755_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/082/SRR12079782/SRR12079782_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/038/SRR12079738/SRR12079738_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/079/SRR12079779/SRR12079779_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/053/SRR12079753/SRR12079753_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/026/SRR12079726/SRR12079726_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/067/SRR12079767/SRR12079767_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/041/SRR12079741/SRR12079741_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/077/SRR12079777/SRR12079777_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/089/SRR12079789/SRR12079789_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/083/SRR12079783/SRR12079783_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/065/SRR12079765/SRR12079765_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/071/SRR12079771/SRR12079771_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/031/SRR12079731/SRR12079731_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/025/SRR12079725/SRR12079725_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/095/SRR12079795/SRR12079795_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/028/SRR12079728/SRR12079728_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/092/SRR12079792/SRR12079792_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/061/SRR12079761/SRR12079761_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/080/SRR12079780/SRR12079780_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/037/SRR12079737/SRR12079737_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/023/SRR12079723/SRR12079723_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/068/SRR12079768/SRR12079768_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/049/SRR12079749/SRR12079749_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/085/SRR12079785/SRR12079785_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/044/SRR12079744/SRR12079744_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/035/SRR12079735/SRR12079735_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/056/SRR12079756/SRR12079756_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/097/SRR12079797/SRR12079797_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/094/SRR12079794/SRR12079794_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/032/SRR12079732/SRR12079732_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/073/SRR12079773/SRR12079773_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/070/SRR12079770/SRR12079770_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/047/SRR12079747/SRR12079747_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR120/082/SRR12079782/SRR12079782_2.fastq.gzprimaryOK200GenomicsVanderbilt University Medical Centerhttps://www.ebi.ac.uk/ena/browser/view/PRJNA641530The bacterial pathogen, Helicobacter pylori, which ubfects half of the world's population, is the primary causal factor for stomach cancer, with an attributable risk of approximately 90%. This infection universally causes chronic gastric inflammation in all those infected, and this chronic active gastritis can progress to gastric cancer.Herein, we show that electrophiles may represent a molecular bridge between inflammation and formation of somatic genomic abnormalities in the gastrointestinal epithelium and thus favor carcinogenesis. We found that 5-ethyl-2-hydroxybenzylamine (EtHOBA), a potent scavenger of all dicarbonyl electrophiles, which reacts at a rate 3 orders of magnitude faster than lysine and protects histones from covalent adduction by dicarbonyl electrophiles, prevents adduct formation with cellular macromolecules in the inflamed mucosa, epithelial genomic instability, and cancer development in two models of H. pylori-induced gastric cancer and in a model of colitis-associated cancer (CAC).xref:EuropePMC:PMC7956217ENAfalseA scavenger of electrophiles suppresses inflammation-mediated carcinogenesis in the gastrointestinal tract2023-08-012023-08-01PRJNA641530