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HAND is a spectrum of neurocognitive deficits linked to impairments in the prefrontal cortex (PFC) and hippocampus, areas controlling higher cognitive processes. Studies in HIV+ patients implicate acute viremia and inflammation in driving central nervous system (CNS) impairment. However, the timing and implications of viral dissemination to the CNS, particularly the PFC and hippocampus, remain undefined. We tested the hypothesis that HIV-1 is rapidly and actively established within areas of the CNS responsible for controlling cognition. Overall design: Comparison of transcriptome profiles across select neural tissues in SHIV model.ENArhesus macaque, Rhesus Macaque, Controlling, preventive therapy, Rhesus Macaques, Monkey, reference sample, Macaque, Macaca mulatta lasiotas, prophylaxis, nervous tissue, RNA-seq, rhesus monkeys, rhesus macaques, Rhesus Monkeys, Macaca mulatta lasiota, prevention, Chinese Rhesus Macaque, preventive measures, nerve tissue, portion of neural tissue, control, Cercopithecus mulatta, Rhesus., Rhesus monkey, Whole Transcriptome Shotgun Sequencing, Chinese Rhesus Macaques, Rhesus Monkey, Rhesus, Chinese, prevention and control, Controlledrhesus macaque, Rhesus Macaque, Controlling, preventive therapy, Rhesus Macaques, Monkey, reference sample, Macaque, Macaca mulatta lasiotas, prophylaxis, nervous tissue, RNA-seq, rhesus monkeys, rhesus macaques, Rhesus Monkeys, Macaca mulatta lasiota, prevention, Chinese Rhesus Macaque, preventive measures, nerve tissue, portion of neural tissue, control, Cercopithecus mulatta, Rhesus., Rhesus monkey, Whole Transcriptome Shotgun Sequencing, Chinese Rhesus Macaques, Rhesus Monkey, Rhesus, Chinese, prevention and control, ControlledfalseRNA-seq of select neural tissue in SHIV infected and control rhesus macaquesRNA-seq of select neural tissue in SHIV infected and control rhesus macaques2025-09-242020-09-11PRJNA662395GSE157690954436203187