ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR127/037/SRR12728637/SRR12728637.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR127/038/SRR12728638/SRR12728638.fastq.gzprimaryOK200GenomicsInstitute of Molecular Medicine and Genetics Shandong University School of Medicinehttps://www.ebi.ac.uk/ena/browser/view/PRJNA666132Homo sapiensApproximately 30% of cases are resistant to TAM, which has become a major obstacle for breast cancer therapy.In this study, we demonstrated that CUL4B promotes TAM resistance in breast cancer cells through miR-32-5p/ER-α36 axis. CUL4B is overexpressed in TAM-resistant breast cancer cells and positively correlates with the levels of ER-α36 protein in human breast cancer specimens. Mechanistically, CUL4B positively regulates ER-α36 expression by epigenetically repressing the transcription of miR-32-5p. These findings provide not only a mechanistic insight into the role of CUL4B in regulating TAM sensitivity but also a potential target for the therapy of breast cancer. Overall design: We generated transciptome data from human breast cancer cells that Knockdown CUL4B and its controlENAMRXSC, Breast Carcinoma, Human Mammary Neoplasm, primary breast cancer, Carcinoma, RNA, malignant tumor of the breast, CUL-4B, human being, Breast Carcinomas, "breast neoplasm" EXACT [MTH:120], RNA Sequence Determination, RNA Sequence Determinations, Sequence Determination, AA409770., Neoplasms, RNA Sequence, Modern, mammary neoplasm, Mammary Cancers, Human Mammary Neoplasms, MRXS15, Tumor, "breast tumor" EXACT [NCI2004_11_17:C2910], Cell, Determinations, Human, Breast Malignant Neoplasm, Breast Malignant Tumor, Homo sapiens, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Mammary Carcinomas, Breast Tumor, Neoplasm, Human Mammary Carcinoma, "mammary tumor" EXACT [CSP2005:2016-0671], NOS, breast tumor, cancer of the breast, Analysis, Malignant Neoplasm of Breast, Man, SFM2, Carcinomas, BC, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, Breast Neoplasm, Man (Taxonomy), Analyses, Determination, Mammary Neoplasm, Mammary Carcinoma, MRXHF2, Human Mammary Carcinomas, Cancers, "mammary neoplasm" RELATED [], mKIAA0695, Sequence Determinations, Sequencing, human, Cancer of the Breast, 2700050M05Rik, RNA Sequence Analyses, breast cancer, cancer of breast, Malignant Tumor of Breast, Mammary, Mammary Cancer, RNA Sequence Analysis, Modern Man, Breast Tumors, Breast Cancer, Breast Malignant Tumors, RNA Sequencing, Cancer of Breast, Breast, mammary cancer, cancer, mammary tumor, Breast Malignant Neoplasms, breast, Sequence Analyses, Tumors, CancerMRXSC, Breast Carcinoma, Human Mammary Neoplasm, primary breast cancer, Carcinoma, RNA, malignant tumor of the breast, CUL-4B, human being, Breast Carcinomas, "breast neoplasm" EXACT [MTH:120], RNA Sequence Determination, RNA Sequence Determinations, Sequence Determination, AA409770., Neoplasms, RNA Sequence, Modern, mammary neoplasm, Mammary Cancers, Human Mammary Neoplasms, MRXS15, Tumor, "breast tumor" EXACT [NCI2004_11_17:C2910], Cell, Determinations, Human, Breast Malignant Neoplasm, Breast Malignant Tumor, Homo sapiens, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Mammary Carcinomas, Breast Tumor, Neoplasm, Human Mammary Carcinoma, "mammary tumor" EXACT [CSP2005:2016-0671], NOS, breast tumor, cancer of the breast, Analysis, Malignant Neoplasm of Breast, Man, SFM2, Carcinomas, BC, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, Breast Neoplasm, Man (Taxonomy), Analyses, Determination, Mammary Neoplasm, Mammary Carcinoma, MRXHF2, Human Mammary Carcinomas, Cancers, "mammary neoplasm" RELATED [], mKIAA0695, Sequence Determinations, Sequencing, human, Cancer of the Breast, 2700050M05Rik, RNA Sequence Analyses, breast cancer, cancer of breast, Malignant Tumor of Breast, Mammary, Mammary Cancer, RNA Sequence Analysis, Modern Man, Breast Tumors, Breast Cancer, Breast Malignant Tumors, RNA Sequencing, Cancer of Breast, Breast, mammary cancer, cancer, mammary tumor, Breast Malignant Neoplasms, breast, Sequence Analyses, Tumors, CancerfalseRNA sequencing of human breast cancer cells with CUL4B knockdownRNA sequencing of human breast cancer cells with CUL4B knockdown2025-09-242022-10-07PRJNA666132GSE1586519606