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of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA670004"],"scientific_name":["Homo sapiens"],"tag":["xref:PubMed:36405397"],"long_description":["Using a recently optimized method for separation of brain-derived EVs (bdEVs) from post-mortem tissues, we obtained bdEVs of 23 AD patients with different APOE genotypes and 7 controls. RNA was extracted from brain homogenate, an intermediate (\"10K\") EV fraction, and more purified EVs and subjected to small RNA sequencing. Numerous RNA species varied with AD pathology and APOE genotypes. Dysregulation of some of these molecules has been implicated in amyloid processing, neurodegeneration and metabolic functions. Molecular differences of bdEVs may thus reflect or play a role in modulating AD progression. Overall design: Total RNA was extracted from brain tissue (BH), 10K, and EVs of 23 AD patient with different APOE genotypes, as well as from 7 control brains."],"repository":["ENA"],"description_synonyms":["the brain, APO-E, Apo E Isoproteins, deceased, Presenile Alzheimer Dementia, ALZHEIMERS DIS, Exovesicles, RNA Sequence Determination, Alzheimers Diseases, Apoptotic Body, Bodies, Early Onset, Sequence Determination, Sclerosis, RNA Sequence, Vesicles, Genotypes., Extracellular Vesicle, Cardiac Death, Early Onset Alzheimer Disease, Focal Onset, Alzheimer's disease, unspecified (disorder), ALZHEIMER DIS, Primary Senile Degenerative, AD, unspecified, APOEA, reduced, [X]Dementia in Alzheimer's disease, synganglion, tiny, Analysis, portion of tissue, LPG, LATE ONSET ALZHEIMER DIS, Familial Alzheimer Disease (FAD), Alzheimer Diseases, Analyses, DAT - Dementia Alzheimer's type, Determination, Tissue, hypoplasia, Isoproteins, apo-E, suprasegmental levels of nervous system, Focal Onset Alzheimer's Disease, ApoE, Sequence Determinations, Late Onset Alzheimer Disease, APOE, Sequencing, FOCAL ONSET ALZHEIMERS DIS, Presenile Dementia, RNA Sequence Analyses, AD - Alzheimer's disease, Alzheimer Disease, Clients, Extracellular, Alzheimer Type Dementia, AD2, Apo-E, RNA Sequencing, ALZHEIMER DIS EARLY ONSET, Apolipoprotein E Isoproteins, Alzheimer's disease (disorder), Presenile, Alzheimers Dementia, Alzheimers disease, Apoproteins E, Sequence Analyses, small, Alzheimer Senile Dementia, Senile, RNA, Disease, Alzheimer disease, suprasegmental structures, RNA Sequence Determinations, Alzheimer Syndrome, Acute Confusional Senile Dementia, Apoptotic Bodies, familial, encephalon, Client, Alzheimer's Dementia, Determinations, Primary Senile Degenerative Dementia, AI255918, Vesicle, [X]Dementia in Alzheimer's disease (disorder), Alzheimer Type, LDLCQ5, Alzheimer Dementias, Genogroup, Alzheimer's Diseases, Apoptotic, post-mortem, tissue portion, NOS, simple tissue, Death, Exovesicle, Dementia, Alzheimers, underdeveloped, Dementia in Alzheimer's disease, Alzheimer, Encephalon, Apoprotein (E), Alzheimer's Disease Pathway, Dementias, Alzheimer Type Senile Dementia, Apolipoprotein E, Alzheimer-Type (ATD), Alzheimer Dementia, Body, Alzheimer Sclerosis, Genogroups, Senile Dementia, Late Onset, Patient, Familial (FAD), RNA Sequence Analysis, Apo E, Acute Confusional, Dementia in Alzheimer's disease (disorder), Alzheimer-Type Dementia (ATD), Alzheimer's Disease, Familial Alzheimer Diseases (FAD), Alzheimer Type Dementia (ATD), Dementia of the Alzheimer's type"],"name_synonyms":["the brain, APO-E, Apo E Isoproteins, deceased, Presenile Alzheimer Dementia, ALZHEIMERS DIS, Exovesicles, RNA Sequence Determination, Alzheimers Diseases, Apoptotic Body, Bodies, Early Onset, Sequence Determination, Sclerosis, RNA Sequence, Vesicles, Genotypes., Extracellular Vesicle, Cardiac Death, Early Onset Alzheimer Disease, Focal Onset, Alzheimer's disease, unspecified (disorder), ALZHEIMER DIS, Primary Senile Degenerative, AD, unspecified, APOEA, reduced, [X]Dementia in Alzheimer's disease, synganglion, tiny, Analysis, portion of tissue, LPG, LATE ONSET ALZHEIMER DIS, Familial Alzheimer Disease (FAD), Alzheimer Diseases, Analyses, DAT - Dementia Alzheimer's type, Determination, Tissue, hypoplasia, Isoproteins, apo-E, suprasegmental levels of nervous system, Focal Onset Alzheimer's Disease, ApoE, Sequence Determinations, Late Onset Alzheimer Disease, APOE, Sequencing, FOCAL ONSET ALZHEIMERS DIS, Presenile Dementia, RNA Sequence Analyses, AD - Alzheimer's disease, Alzheimer Disease, Clients, Extracellular, Alzheimer Type Dementia, AD2, Apo-E, RNA Sequencing, ALZHEIMER DIS EARLY ONSET, Apolipoprotein E Isoproteins, Alzheimer's disease (disorder), Presenile, Alzheimers Dementia, Alzheimers disease, Apoproteins E, Sequence Analyses, small, Alzheimer Senile Dementia, Senile, RNA, Disease, Alzheimer disease, suprasegmental structures, RNA Sequence Determinations, Alzheimer Syndrome, Acute Confusional Senile Dementia, Apoptotic Bodies, familial, encephalon, Client, Alzheimer's Dementia, Determinations, Primary Senile Degenerative Dementia, AI255918, Vesicle, [X]Dementia in Alzheimer's disease (disorder), Alzheimer Type, LDLCQ5, Alzheimer Dementias, Genogroup, Alzheimer's Diseases, Apoptotic, post-mortem, tissue portion, NOS, simple tissue, Death, Exovesicle, Dementia, Alzheimers, underdeveloped, Dementia in Alzheimer's disease, Alzheimer, Encephalon, Apoprotein (E), Alzheimer's Disease Pathway, Dementias, Alzheimer Type Senile Dementia, Apolipoprotein E, Alzheimer-Type (ATD), Alzheimer Dementia, Body, Alzheimer Sclerosis, Genogroups, Senile Dementia, Late Onset, Patient, Familial (FAD), RNA Sequence Analysis, Apo E, Acute Confusional, Dementia in Alzheimer's disease (disorder), Alzheimer-Type Dementia (ATD), Alzheimer's Disease, Familial Alzheimer Diseases (FAD), Alzheimer Type Dementia (ATD), Dementia of the Alzheimer's type"],"additional_accession":[]},"is_claimable":false,"name":"Small RNA sequencing of brain-derived extracellular vesicles from post-mortem brain tissue of controls and Alzheimer's disease patients with different APOE genotypes","description":"Small RNA sequencing of brain-derived extracellular vesicles from post-mortem brain tissue of controls and Alzheimer's disease patients with different APOE genotypes","dates":{"last_updated":"2025-09-24","first_public":"2020-10-21"},"accession":"PRJNA670004","cross_references":{"GEO":["GSE159541"],"taxon":["9606"],"PubMed":["36405397"]}}