{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["CONACYT-IMSS"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA671309"],"scientific_name":["Homo sapiens"],"long_description":["Dysregulation of glyco-gene expression in cancer can lead to aberrant glycans and glycoconjugates, which in turn can promote tumorigenesis. Cervical cancer display augmentation of aberrant sialylated glycans and increase of glyco-genes, which encoded enzymes participate in the sialylation pathways. Besides sialiltranferases, other glyco-genes, analyzed individually are reported as altered in cervical cancer. Here we show a comprehensive analysis of glyco-gene expression in cervical cancer to obtain a wide scenery of global changes in glycosylation pathways. First, we compared glyco-gene expression between normal tissue and cervical cancer. Second, we analyzed the glycogene expression in subtypes of cc to obtain hallmarks of glyco-gene expression in each case. Our results indicate that in cervical cancer the GPI-anchored biosynthesis is increased in cc while the synthesis of chondroitin and dermatan sulfate are decreased. Moreover, data show that adenocarcinoma displayed a homogenous glyco-gene expression pattern, where chondroitin /dermatan sulfate and heparan sulfate glycogenes are decreased, while keratan sulfate genes are increased. Dysregulation of glyco-gene expression in cancer can lead to aberrant glycans and glycoconjugates, which in turn can promote tumorigenesis. Cervical cancer display augmentation of aberrant sialylated glycans and increase of glyco-genes, which encoded enzymes participate in the sialylation pathways. Besides sialiltranferases, other glyco-genes, analyzed individually are reported as altered in cervical cancer. Here we show a comprehensive analysis of glyco-gene expression in cervical cancer to obtain a wide scenery of global changes in glycosylation pathways. First, we compared glyco-gene expression between normal tissue and cervical cancer. Second, we analyzed the glycogene expression in subtypes of cc to obtain hallmarks of glyco-gene expression in each case. Our results indicate that in cervical cancer the GPI-anchored biosynthesis is increased in cc while the synthesis of chondroitin and dermatan sulfate are decreased. Moreover, data show that adenocarcinoma displayed a homogenous glyco-gene expression pattern, where chondroitin /dermatan sulfate and heparan sulfate glycogenes are decreased, while keratan sulfate genes are increased. Overall design: Two-condition experiment, normal cervix tissue and cervical cancer tissue. One replicate array. 10 µg of total pooled RNA from each case were used for cDNA synthesis incorporating dUTP-Alexa555 (for normal cervix) or dUTP-Alexa647 (for cervical cancer) employing the First-Strand cDNA labeling kit (Invitrogen). Incorporation of fluorophore was analyzed by using the absorbance at 555 nm for Alexa555 and 650 nm for Alexa647. Equal quantities of labeled cDNA were hybridized using hybridization solution UniHyb (TeleChem International INC). The arrays were incubated for 14 h at 42°C, and then washed tree times with 1X SCC, 0.05 % SDS at room temperature."],"tag":["xref:PubMed:34540372"],"repository":["ENA"],"description_synonyms":["Adenocarcinoma, tumor of the cervix uteri, Materials, O-linked Glycosylations, GlcNAcylation, Adenomas, Galactosylation, Neoplasms, Oxyphilic Adenocarcinoma, Gene, Galactosylations, N-linked Glycosylations, Malignant, ADNOS, Cervical., cancer of cervix, Granular Cell Adenocarcinomas, N-linked, O-linked Glycosylation, glycosylation, Glycosylation, \"adenocarcinoma\" EXACT [NCI2004_11_17:C2852], Granular Cell Adenocarcinoma, no subtype (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:35917007], Tubular Carcinoma, Basal Cell Adenocarcinomas, Cervical Neoplasm, tumor of the Cervix Uteri, Cribriform Carcinoma, Genetic, Adenoma, Protein Glycosylations, Granular Cell Carcinoma, Tubular Adenocarcinoma, N-Acetylglucosaminylation, tumour of the cervix uteri, Tubular Carcinomas, Cribriform Carcinomas, Sialylation, CERCA, Cervical Neoplasms, Granular Cell Carcinomas, Phosphoglycosylation, O-linked, Fucosylation, Cancer of Cervix, cervix cancer, Cervix Neoplasm, N-Acetylglucosaminylations, Cervix Cancer, N-linked Glycosylation, Cancer, uterine cervical neoplasm, Carcinoma, Oxyphilic, cervix uteri cancer, Cervix Neoplasms, Protein Glycosylation, Basal Cell, Glycosylations, Cistrons, Adenocarcinomas, Uterine, Fucosylations, Cancer of the Uterine Cervix, O linked Glycosylation, Cervical Cancer, \"adenocarcinoma, Tubular, Phosphoglycosylations, Malignant Adenoma, cervical cancer, Uterine Cervical, Protein, Cervical Cancers, Neoplasm, Genetic Materials, GlcNAcylations, NOS, Granular Cell, Oxyphilic Adenocarcinomas, cancer of the cervix, Basal Cell Adenocarcinoma, Genetic Material, uterine cervix cancer, Carcinomas, cancer of the uterine cervix, cancer of uterine cervix, N linked Glycosylation, \"adenocarcinoma\" EXACT [CSP2005:2000-0386], cervical neoplasm, Cancer of the Cervix, Sialylations, Cribriform, Uterine Cervical Cancer, \"adenocarcinomas\" EXACT [SNOMEDCT_2005_07_31:189578007], Tubular Adenocarcinomas, Malignant Adenomas, Uterine Cervical Cancers, Material, N Acetylglucosaminylation, Cervix, neoplasm of uterine cervix, Cistron, Uterine Cervical Neoplasm, \"adenocarcinoma NOS (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:189582009], Cervical"],"name_synonyms":["Adenocarcinoma, tumor of the cervix uteri, Materials, O-linked Glycosylations, GlcNAcylation, Adenomas, Galactosylation, Neoplasms, Oxyphilic Adenocarcinoma, Gene, Galactosylations, N-linked Glycosylations, Malignant, ADNOS, Cervical., cancer of cervix, Granular Cell Adenocarcinomas, N-linked, O-linked Glycosylation, glycosylation, Glycosylation, \"adenocarcinoma\" EXACT [NCI2004_11_17:C2852], Granular Cell Adenocarcinoma, no subtype (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:35917007], Tubular Carcinoma, Basal Cell Adenocarcinomas, Cervical Neoplasm, tumor of the Cervix Uteri, Cribriform Carcinoma, Genetic, Adenoma, Protein Glycosylations, Granular Cell Carcinoma, Tubular Adenocarcinoma, N-Acetylglucosaminylation, tumour of the cervix uteri, Tubular Carcinomas, Cribriform Carcinomas, Sialylation, CERCA, Cervical Neoplasms, Granular Cell Carcinomas, Phosphoglycosylation, O-linked, Fucosylation, Cancer of Cervix, cervix cancer, Cervix Neoplasm, N-Acetylglucosaminylations, Cervix Cancer, N-linked Glycosylation, Cancer, uterine cervical neoplasm, Carcinoma, Oxyphilic, cervix uteri cancer, Cervix Neoplasms, Protein Glycosylation, Basal Cell, Glycosylations, Cistrons, Adenocarcinomas, Uterine, Fucosylations, Cancer of the Uterine Cervix, O linked Glycosylation, Cervical Cancer, \"adenocarcinoma, Tubular, Phosphoglycosylations, Malignant Adenoma, cervical cancer, Uterine Cervical, Protein, Cervical Cancers, Neoplasm, Genetic Materials, GlcNAcylations, NOS, Granular Cell, Oxyphilic Adenocarcinomas, cancer of the cervix, Basal Cell Adenocarcinoma, Genetic Material, uterine cervix cancer, Carcinomas, cancer of the uterine cervix, cancer of uterine cervix, N linked Glycosylation, \"adenocarcinoma\" EXACT [CSP2005:2000-0386], cervical neoplasm, Cancer of the Cervix, Sialylations, Cribriform, Uterine Cervical Cancer, \"adenocarcinomas\" EXACT [SNOMEDCT_2005_07_31:189578007], Tubular Adenocarcinomas, Malignant Adenomas, Uterine Cervical Cancers, Material, N Acetylglucosaminylation, Cervix, neoplasm of uterine cervix, Cistron, Uterine Cervical Neoplasm, \"adenocarcinoma NOS (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:189582009], Cervical"],"additional_accession":[]},"is_claimable":false,"name":"Hallmarks of glyco-genes expression and their glycosylation pathways in squamous and adenocarcinoma cervical cancer","description":"Hallmarks of glyco-genes expression and their glycosylation pathways in squamous and adenocarcinoma cervical cancer","dates":{"last_updated":"2025-09-24","first_public":"2020-11-02"},"accession":"PRJNA671309","cross_references":{"GEO":["GSE159976"],"taxon":["9606"],"PubMed":["34540372"]}}