{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/064/SRR13055364/SRR13055364.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/068/SRR13055368/SRR13055368.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/070/SRR13055370/SRR13055370.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/066/SRR13055366/SRR13055366.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/065/SRR13055365/SRR13055365.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/067/SRR13055367/SRR13055367.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/063/SRR13055363/SRR13055363.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR130/069/SRR13055369/SRR13055369.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["iBV, University of Nice"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA678296"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:34623260"],"long_description":["The retinoic acid (RA) signaling pathway is essential for cardiac development however, cardiomyocytes, the main cell type of the heart, are considered to be unresposive to RA signaling. The goal of this study was to examine the effects of all-trans RA (atRA) treatment on cardiomyocytes isolated from E18.5 mouse embryos. We found that cardiomyocytes, contrary to previous findings, are indeed repsonsive to RA signaling and that many genes involved in cardiac developmental and repair processes were significantly deregulated upon atRA trearment. These findings have important implications for the heart development and regeneration fields. Overall design: Transcriptional profiles of primary murine E18.5 cardiomyocytes treated with atRA or DMSO for 48 hours. Four biological replicates per treatment."],"repository":["ENA"],"description_synonyms":["all-trans-vitamin A1 acid, wide/broad, Tretin M, tretinoin, determination, Tretinoin Zinc Salt, Refissa, trans-Retinoic Acid, 8-all-trans-tetraenoic acid, 4E, broad, 8E-tetraenoic acid, Dermairol, Tretinoin Potassium, beta all trans Retinoic Acid, Ro 1-5488, Tri-luma, Tretinoin, trans-retinoic acid, 6-trimethyl-1-cyclohexen-1-yl)-2, AGN 100335, all-trans retinoic acid, Potassium Salt, all-trans-Retinoic Acid, Retinoic Acid, 8-nonatetraenoic acid, Tretinoin Sodium, all-trans-vitamin A acid, Biacna, 6-trimethylcyclohex-1-enyl)nona-2, Retin A, Cordes vas, chemical analysis, retinoic acid, 3, all-trans-tretinoin, all-trans-Retinoic, 4, 6, Retin-A, 6-trimethyl-1-cyclohexene-1-yl)-2, Vesanoid, Acide retinoique (French), Stieva-A, 6-trimethylcyclohex-1-en-1-yl)nona-2, Retinoic acid, Retinoic, beta-Retinoic acid, Acid, tretinoina, all-trans-beta-Retinoic acid, Genomes, 6E, Renova, Salt, Tretinoin Zinc, all trans Retinoic Acid, beta-all-trans-Retinoic Acid, tretinoinum, Atralin, Tretinoin Potassium Salt, Betarretin, whole genome, 8E)-3, 6-trimethylcyclohexen-1-yl)nona-2E, trans Retinoic Acid, Tretinoin Sodium Salt, 6-trimethyl-1-cyclohexenyl)nona-2, Zinc Salt, wide, Sodium Salt, 7-dimethyl-9-(2, beta-all-trans-Retinoic, Altreno, Vitamin A., all-(E)-retinoic acid, Avita, vitamin A acid, assay, Retisol-A, (all-E)-3, 8-tetraenoic acid, Vitamin A Acid, tretinoine, (2E, trans-Retinoic, Veltin"],"name_synonyms":["all-trans-vitamin A1 acid, wide/broad, Tretin M, tretinoin, determination, Tretinoin Zinc Salt, Refissa, trans-Retinoic Acid, 8-all-trans-tetraenoic acid, 4E, broad, 8E-tetraenoic acid, Dermairol, Tretinoin Potassium, beta all trans Retinoic Acid, Ro 1-5488, Tri-luma, Tretinoin, trans-retinoic acid, 6-trimethyl-1-cyclohexen-1-yl)-2, AGN 100335, all-trans retinoic acid, Potassium Salt, all-trans-Retinoic Acid, Retinoic Acid, 8-nonatetraenoic acid, Tretinoin Sodium, all-trans-vitamin A acid, Biacna, 6-trimethylcyclohex-1-enyl)nona-2, Retin A, Cordes vas, chemical analysis, retinoic acid, 3, all-trans-tretinoin, all-trans-Retinoic, 4, 6, Retin-A, 6-trimethyl-1-cyclohexene-1-yl)-2, Vesanoid, Acide retinoique (French), Stieva-A, 6-trimethylcyclohex-1-en-1-yl)nona-2, Retinoic acid, Retinoic, beta-Retinoic acid, Acid, tretinoina, all-trans-beta-Retinoic acid, Genomes, 6E, Renova, Salt, Tretinoin Zinc, all trans Retinoic Acid, beta-all-trans-Retinoic Acid, tretinoinum, Atralin, Tretinoin Potassium Salt, Betarretin, whole genome, 8E)-3, 6-trimethylcyclohexen-1-yl)nona-2E, trans Retinoic Acid, Tretinoin Sodium Salt, 6-trimethyl-1-cyclohexenyl)nona-2, Zinc Salt, wide, Sodium Salt, 7-dimethyl-9-(2, beta-all-trans-Retinoic, Altreno, Vitamin A., all-(E)-retinoic acid, Avita, vitamin A acid, assay, Retisol-A, (all-E)-3, 8-tetraenoic acid, Vitamin A Acid, tretinoine, (2E, trans-Retinoic, Veltin"],"additional_accession":[]},"is_claimable":false,"name":"Genome wide sequencing analysis of primary cardiomyocytes treated with all-trans retinoic acid","description":"Genome wide sequencing analysis of primary cardiomyocytes treated with all-trans retinoic acid","dates":{"last_updated":"2025-09-24","first_public":"2021-04-04"},"accession":"PRJNA678296","cross_references":{"GEO":["GSE161429"],"taxon":["10090"],"PubMed":["34623260"]}}