ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/039/SRR13159539/SRR13159539_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/032/SRR13159532/SRR13159532_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/037/SRR13159537/SRR13159537_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/036/SRR13159536/SRR13159536_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/035/SRR13159535/SRR13159535_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/030/SRR13159530/SRR13159530_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/038/SRR13159538/SRR13159538_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/031/SRR13159531/SRR13159531_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/035/SRR13159535/SRR13159535_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/034/SRR13159534/SRR13159534_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/031/SRR13159531/SRR13159531_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/040/SRR13159540/SRR13159540_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/039/SRR13159539/SRR13159539_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/038/SRR13159538/SRR13159538_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/033/SRR13159533/SRR13159533_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/032/SRR13159532/SRR13159532_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/030/SRR13159530/SRR13159530_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/036/SRR13159536/SRR13159536_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/037/SRR13159537/SRR13159537_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/034/SRR13159534/SRR13159534_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/033/SRR13159533/SRR13159533_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/040/SRR13159540/SRR13159540_2.fastq.gzprimaryOK200GenomicsInstitute of Psoriasis, Tongji University School of Medicine, Dermatology, Shanghai Skin Disease Hospitalhttps://www.ebi.ac.uk/ena/browser/view/PRJNA681231Mus musculusPurpose: To compare epidermal LC transcriptomes of control group (wild-type IMQ-untreated C57/BL6 mice) and IMQ group (wild-type IMQ-treated C57/BL6 mice). Results: KEGG pathway analysis implied that lesional LCs were highly enriched in several inflammatory signalling pathways, including cytokine-cytokine receptor interactions, Th1, Th2 and Th17 cell differentiation, tumor necrosis factor signalling and IL-17 signalling pathways, complement and coagulation cascades, and NOD-like receptor signalling and PI3K-Akt signalling pathways. Gene set enrichment analysis plots revealed enrichment of cytokine activity, chemoattractant activity, protein lipid complex binding, and low-density lipoprotein particle binding gene sets in LCs from IMQ+ mice compared with IMQ- mice. Conclusions: These results confirmed a proinflammatory role for epidermal LCs in the pathogenesis of psoriasis. Overall design: Epidermal LC Transcriptomes of IMQ-Induced Psoriasis-Like DermatitisENADermal Dendritic Cells, Dendritic Cells, "dermatitis" EXACT [NCI2004_11_17:C2983], Langerhans Cell, Dermal, determination, Dermatitis, Psoriasis and similar disorders, Pustular Psoriasis of Palms and Soles, "Dermatitis (disorder) [Ambiguous]" EXACT [SNOMEDCT_2005_07_31:4979002], Skin Dendritic Cell, Psoriases, "Dermatitis NOS" EXACT [SNOMEDCT_2005_07_31:267847004], PUSTULAR PSORIASIS OF PALMS SOLES, Psoriasis and similar disorders (disorder), OTHER PSORIASIS, Messenger, R837, NOS" EXACT [MTHICD9_2006:692.9], Low, psoriasis, Dendritic Cell, inflammation of skin, R-837, Other psoriasis and similar disorders (disorder), Other psoriasis and similar disorders, Non Polyadenylated, Aldara, PITYRIASIS NEC & NOS, me75, "Dermatitis (disorder)" EXACT [SNOMEDCT_2005_07_31:182782007], Polyadenylated Messenger, Palmoplantaris Pustulosis, messenger RNA, Zyclara, D17Mit170, R 837, Psoriasis and similar disorders NOS (disorder), T1, skin inflammation, template RNA, "dermatitis" EXACT [CSP2005:4008-0032]., zone of skin inflammation, 5-c)quinolin-4-amine, inflammation of the skin, "skin inflammation NOS" EXACT [SNOMEDCT_2005_07_31:156388001], Skin Dendritic, RNA, inflammatory skin disease, cou, Epidermal Dendritic Cell, Polyadenylated, Epidermal Dendritic, 1H-Imidazo(4, Messenger RNA, Tl3, Tl2, Cell, Other and unspecified pityriasis, inflammation of zone of skin, "Other dermatitis due to solar radiation" EXACT [], Lr, 1-Isobutyl-1H-imidazo(4, Pustulosis of Palms and Soles, Poly(A)+ mRNA, Inflammatory skin disease, chemical analysis, S 26308, INSDC_feature:mRNA, Other psoriasis and similar disorders excluding psoriatic arthropathy, PSORIAS RELATED DIS NEC, Polyadenylated RNA, Skin, Psoriasis and similar disorders NOS, Polyadenylated Messenger RNA, "Dermatitis NOS" EXACT [SNOMEDCT_2005_07_31:156358005], PUSTULOSIS OF PALMS SOLES, Dermal Dendritic, Poly(A)+ RNA, Non Polyadenylated mRNA, protein_coding_transcript, mRNA, Poly(A) Tail, "skin inflammation NOS (disorder)" EXACT [SNOMEDCT_2005_07_31:267856007], 1-(2-methylpropyl)-, "Dermatitis, Non-Polyadenylated, Pustulosis Palmaris et Plantaris, Langerhans, Non-Polyadenylated mRNA, Skin Dendritic Cells, Dermatitides, Epidermal, "Dermatitis NOS (disorder)" EXACT [SNOMEDCT_2005_07_31:200884006], Epidermal Dendritic Cells, Cells, Bra, S-26308, Psoriasis and similar disorders (navigational concept), assay, Polyadenylated mRNA, Poly(A) RNA, Dermal Dendritic Cell, "Other chronic dermatitis due to solar radiation" EXACT []Dermal Dendritic Cells, Dendritic Cells, "dermatitis" EXACT [NCI2004_11_17:C2983], Langerhans Cell, Dermal, determination, Dermatitis, Psoriasis and similar disorders, Pustular Psoriasis of Palms and Soles, "Dermatitis (disorder) [Ambiguous]" EXACT [SNOMEDCT_2005_07_31:4979002], Skin Dendritic Cell, Psoriases, "Dermatitis NOS" EXACT [SNOMEDCT_2005_07_31:267847004], PUSTULAR PSORIASIS OF PALMS SOLES, Psoriasis and similar disorders (disorder), OTHER PSORIASIS, Messenger, R837, NOS" EXACT [MTHICD9_2006:692.9], Low, psoriasis, Dendritic Cell, inflammation of skin, R-837, Other psoriasis and similar disorders (disorder), Other psoriasis and similar disorders, Non Polyadenylated, Aldara, PITYRIASIS NEC & NOS, me75, "Dermatitis (disorder)" EXACT [SNOMEDCT_2005_07_31:182782007], Polyadenylated Messenger, Palmoplantaris Pustulosis, messenger RNA, Zyclara, D17Mit170, R 837, Psoriasis and similar disorders NOS (disorder), T1, skin inflammation, template RNA, "dermatitis" EXACT [CSP2005:4008-0032]., zone of skin inflammation, 5-c)quinolin-4-amine, inflammation of the skin, "skin inflammation NOS" EXACT [SNOMEDCT_2005_07_31:156388001], Skin Dendritic, RNA, inflammatory skin disease, cou, Epidermal Dendritic Cell, Polyadenylated, Epidermal Dendritic, 1H-Imidazo(4, Messenger RNA, Tl3, Tl2, Cell, Other and unspecified pityriasis, inflammation of zone of skin, "Other dermatitis due to solar radiation" EXACT [], Lr, 1-Isobutyl-1H-imidazo(4, Pustulosis of Palms and Soles, Poly(A)+ mRNA, Inflammatory skin disease, chemical analysis, S 26308, INSDC_feature:mRNA, Other psoriasis and similar disorders excluding psoriatic arthropathy, PSORIAS RELATED DIS NEC, Polyadenylated RNA, Skin, Psoriasis and similar disorders NOS, Polyadenylated Messenger RNA, "Dermatitis NOS" EXACT [SNOMEDCT_2005_07_31:156358005], PUSTULOSIS OF PALMS SOLES, Dermal Dendritic, Poly(A)+ RNA, Non Polyadenylated mRNA, protein_coding_transcript, mRNA, Poly(A) Tail, "skin inflammation NOS (disorder)" EXACT [SNOMEDCT_2005_07_31:267856007], 1-(2-methylpropyl)-, "Dermatitis, Non-Polyadenylated, Pustulosis Palmaris et Plantaris, Langerhans, Non-Polyadenylated mRNA, Skin Dendritic Cells, Dermatitides, Epidermal, "Dermatitis NOS (disorder)" EXACT [SNOMEDCT_2005_07_31:200884006], Epidermal Dendritic Cells, Cells, Bra, S-26308, Psoriasis and similar disorders (navigational concept), assay, Polyadenylated mRNA, Poly(A) RNA, Dermal Dendritic Cell, "Other chronic dermatitis due to solar radiation" EXACT []falseLow-input mRNA Sequencing Analysis of Epidermal Langerhans cells (LC) from Murine Imiquimod (IMQ)-Induced Psoriasis-Like DermatitisLow-input mRNA Sequencing Analysis of Epidermal Langerhans cells (LC) from Murine Imiquimod (IMQ)-Induced Psoriasis-Like Dermatitis2025-09-242020-12-09PRJNA681231GSE16227410090