{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/046/SRR13172446/SRR13172446.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/043/SRR13172443/SRR13172443.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/042/SRR13172442/SRR13172442.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/047/SRR13172447/SRR13172447.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/044/SRR13172444/SRR13172444.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/045/SRR13172445/SRR13172445.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["VIB Inflammation Research Center, VIB-University of Ghent"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA681782"],"scientific_name":["Mus musculus"],"tag":["xref:PubMed:34625556"],"long_description":["In order to unravel the functional role of the linear deubiquitinase OTULIN, we performed single-cell RNA-sequencing on total skin of mice lacking OTULIN selectively in keratinocytes. Keratinocyte-specific OTULIN knock-out (KO) mice develop delineated inflammatory lesion. Through single-cell analysis on lesional and non-lesional skin of mice lacking OTULIN in keratinocytes, we could identify signalling pathways through which these inflammatory lesions appear, allowing us to get new insights on the molecular events that regulate skin homeostasis and mediate skin inflammation. Overall design: The purpose of this study was to delineate the cellular and molecular changes that occur in the skin when linear deubiquitination is absent in keratinocytes. Total skin was harvested from wild-type (WT) skin and lesional and non-lesional keratinocyte-specific OTULIN knock-out (KO) mice. We FACS sorted live cells from single-cell suspensions of total skin."],"repository":["ENA"],"name_synonyms":["dermis plus epidermis plus hypodermis, 3.4.22.-, the integument, malpighian cell, Ribonucleic, d230, region of skin, pelt, determination, Laboratory, Otf-11, Skn-li, Mus domesticus, mini-ICE, dTAFII250, CASP-14, EfW1, House Mouse, GUM, epidermis, dmTAF[[II]]230, House, dmTAF1, Taf230, Gene Products, Mus musculus domesticus, Mice, Non Polyadenylated, integumentum commune, Skn-1a, TAF250, Taf200, dTAF[[II]]250, skin, TFIID TAF250, cel, Swiss, cell, dermoid system, entire skin, Swiss Mice, Taf1p, SKIN, RNA Gene Products., Non-Polyadenylated RNA, dTAF250, skin organ, Fam91a1, Otf11, keratinized cell of epidermis, TAF, AV220772, skin and subcutaneous tissue, RNA, dTAF[[II]]230, TAF[[II]]250, Oct-11a, ribose nucleic acid, Fam105b, mouse, ribonucleic acids, TAF200, skin zone, l(3)84Ab, m7-1Sapc, RNS, integumental organ, BG:DS00004.13, TAFII-250, TAF250/230, Cell, dTAF230, skin plus hypodermis, TAFII250, Oct11, skin region, Mus, p230, yeast nucleic acid, Ribonukleinsaeure, chemical analysis, BC033609, Mini-ICE, m3Sapc, TAF[[II]]250/230, TFIID, pentosenucleic acids, Ribonucleic acids, Skin-1a, tegument, Skin, C79097, skin benign neoplasm, Taf[[II]]250, Mus musculus, ribonucleic acid, Acid, TAF[[II]]230, Caspase-14 subunit p10, FAM105B, mice, Non Polyadenylated RNA, Swiss Mouse, vertebrate integument, Non-Polyadenylated, House Mice, Caspase-14 subunit p19, TAF[II]250, Ribonucleic Acid, Keratinocyte, MICE, CG17603, TAF[[II]], mKIAA0493, Epoc-1, Laboratory Mice, domesticus, portion of skin, vertebrate epidermis, DmelCG17603, integument, Taf250, SR3-5, Mouse, assay, entire integument, dermal system, Laboratory Mouse, TAF230, TAF1"],"description_synonyms":["dermis plus epidermis plus hypodermis, 3.4.22.-, the integument, malpighian cell, Ribonucleic, d230, region of skin, pelt, determination, Laboratory, Otf-11, Skn-li, Mus domesticus, mini-ICE, dTAFII250, CASP-14, EfW1, House Mouse, GUM, epidermis, dmTAF[[II]]230, House, dmTAF1, Taf230, Gene Products, Mus musculus domesticus, Mice, Non Polyadenylated, integumentum commune, Skn-1a, TAF250, Taf200, dTAF[[II]]250, skin, TFIID TAF250, cel, Swiss, cell, dermoid system, entire skin, Swiss Mice, Taf1p, SKIN, RNA Gene Products., Non-Polyadenylated RNA, dTAF250, skin organ, Fam91a1, Otf11, keratinized cell of epidermis, TAF, AV220772, skin and subcutaneous tissue, RNA, dTAF[[II]]230, TAF[[II]]250, Oct-11a, ribose nucleic acid, Fam105b, mouse, ribonucleic acids, TAF200, skin zone, l(3)84Ab, m7-1Sapc, RNS, integumental organ, BG:DS00004.13, TAFII-250, TAF250/230, Cell, dTAF230, skin plus hypodermis, TAFII250, Oct11, skin region, Mus, p230, yeast nucleic acid, Ribonukleinsaeure, chemical analysis, BC033609, Mini-ICE, m3Sapc, TAF[[II]]250/230, TFIID, pentosenucleic acids, Ribonucleic acids, Skin-1a, tegument, Skin, C79097, skin benign neoplasm, Taf[[II]]250, Mus musculus, ribonucleic acid, Acid, TAF[[II]]230, Caspase-14 subunit p10, FAM105B, mice, Non Polyadenylated RNA, Swiss Mouse, vertebrate integument, Non-Polyadenylated, House Mice, Caspase-14 subunit p19, TAF[II]250, Ribonucleic Acid, Keratinocyte, MICE, CG17603, TAF[[II]], mKIAA0493, Epoc-1, Laboratory Mice, domesticus, portion of skin, vertebrate epidermis, DmelCG17603, integument, Taf250, SR3-5, Mouse, assay, entire integument, dermal system, Laboratory Mouse, TAF230, TAF1"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of skin of keratinocyte-specific OTULIN-deficient mice by single-cell RNA-sequencing","description":"Analysis of skin of keratinocyte-specific OTULIN-deficient mice by single-cell RNA-sequencing","dates":{"last_updated":"2025-09-24","first_public":"2021-08-10"},"accession":"PRJNA681782","cross_references":{"GEO":["GSE162394"],"taxon":["10090"],"PubMed":["34625556"]}}