{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/025/SRR13178325/SRR13178325.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/021/SRR13178321/SRR13178321.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/022/SRR13178322/SRR13178322.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/024/SRR13178324/SRR13178324.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/019/SRR13178319/SRR13178319.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/023/SRR13178323/SRR13178323.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR131/020/SRR13178320/SRR13178320.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["State key laboratories of Agrobiotechnology, College of biological sciences, China Agricutural University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA681928"],"scientific_name":["Mus musculus"],"long_description":["ChIPseq experiments identify that ASPSCR1-TFE3 defines active enhancers across the genome and co-distributes with VCP/p97. RNAseq after knock-down of ASPSCR1-TFE3 or VCP, inhibition of VCP, or overexpression of each in alveolar soft part sarcoma cell lines demonstrates their co-dependence. HiChIP defines chromatin conformations that surround ASPSCR1-TFE3 targets and are lost on VCP knock-down. Overall design: ASPS cell lines, tumors from ASPS mouse model and tumors from ASPS patients are used for ChIP-seq with antibodies against ASPSCR1, VCP, POLII and various histone modifications. RNAseq in ASPS cell lines after application of siRNA against control, ASPSCR1-TFE3, or VCP, or application of VCP inhibitor CB-5083. H3K27ac-HiChIP in the FU-UR-1 cell line at baseline and after 6 days of siRNA against VCP."],"tag":["xref:PubMed:38326311"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"ASPSCR1-TFE3 reprograms transcription by organizing enhancers around hexameric VCP [mASPS_ChIP, ASPL_VCP_Pol2]","description":"ASPSCR1-TFE3 reprograms transcription by organizing enhancers around hexameric VCP [mASPS_ChIP, ASPL_VCP_Pol2]","dates":{"last_updated":"2025-09-24","first_public":"2023-01-27"},"accession":"PRJNA681928","cross_references":{"GEO":["GSE162476"],"taxon":["10090"],"PubMed":["38326311"]}}