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Methods:H522 cells were infected with SARS-CoV-2 at varying multiplicities of infection and samples processed for RNA-seq at 4, 24, 48, 72 and 96 hours post-infection. Results: We provide the transcriptomic and translatomic landscape of SARS-CoV-2-infected H522 cells from multiple RNA-seq libraries. We found that the robust transcriptional upregulation of numerous type I interferon and cell cycle associated genes in SARS-CoV-2-infected cells. Conclusions: Our study represents the detailed analysis of transcriptional responses of H522 cells to SARS-CoV-2 and demonstrates upregulation of key pathways that may paly a role in disease pathogenesis. Overall design: H522 cells were infected with SARS-CoV-2 at varying multiplicities of infection and samples processed for RNA-seq at 4, 24, 48, 72 and 96 hours post-infection."],"tag":["xref:EuropePMC:PMC9929942","xref:PubMed:34214467"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis of SARS-CoV-2 infected H522 human lung adenocarcinoma cells","description":"Transcriptome analysis of SARS-CoV-2 infected H522 human lung adenocarcinoma cells","dates":{"last_updated":"2025-09-24","first_public":"2021-02-01"},"accession":"PRJNA686659","cross_references":{"GEO":["GSE163547"],"taxon":["9606"],"PubMed":["34214467"]}}