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In order to deduce the molecular function of FAN1 in the setting of acute kidney injury and progression to chronic kidney disease, we generated a proximal tubule specific Fan1 knockout mouse model and subjected these mice to cisplatin injury. RNA-seq of the transgenic mice kidneys revealed dysregulation of the DNA damage repair pathway as well as cell cycle associated genes. Together, the data supports for a role of Fan1 in DNA damage repair, and that in its absence results in dysfunctional proximal tubule repair and regeneration upon cisplatin injury. Overall design: 2X150 bp standard RNA-seq was performed using an Illumina HiSeq platform"],"repository":["ENA"],"description_synonyms":["fascin-1, Research Related Injuries, proximal kidney tubule, Platinol, cis-Diamminedichloroplatinum(II), cis-Dichlorodiammineplatinum(II), determination, Cismaplat, Randa, Wound, NSC-119875, Injury and Wounds, renal proximal tubule, p55, Physical, RNA-seq, (SP-4-2)-, Physical Traumas, MTMR15, cis Platinum, injury, proximal tubule, diamminedichloro-, Injuries and Wounds, trauma, HSN, KMIN, Wounds, traumatic injury, Wounds and Injury, Trauma, chemical analysis, (SP-4-2)-diamminedichloridoplatinum, Peyrone's chloride, KIAA1018, Whole Transcriptome Shotgun Sequencing, CDDP, Physical Trauma, Peyrone's salt, Research-Related, FAN1, cis-diammineplatinum(II) dichloride, Fan1, cis-diamminedichloroplatinum, cis-platin, cis-[PtCl2(NH3)2], AI663989, Injury, cis-diamminedichloroplatinum(II), cis-Diamminedichloroplatinum, cis-dichlorodiammineplatinum(II), cis-diamminedichloridoplatinum(II), Neoplatin, cis-DDP, SNL, Diamminodichloride, Dichlorodiammineplatinum, cis-Platinum, cis Diamminedichloroplatinum, [PtCl2(NH3)2], wound, Platinum Diamminodichloride, Platinum, cisplatine, Lederplatin, Briplatin, cisplatin, Injuries, Platamine, cisplatino, Injuries., Kidneys, proximal convoluted tubule, Traumas, Platidiam, Biocisplatinum, Cisplatin, Platino, (SP-4-2)-diamminedichloroplatinum, Research-Related Injuries, TG, cisplatinum, assay, Research-Related Injury, kidney proximal tubule, Platinex"],"name_synonyms":["fascin-1, Research Related Injuries, proximal kidney tubule, Platinol, cis-Diamminedichloroplatinum(II), cis-Dichlorodiammineplatinum(II), determination, Cismaplat, Randa, Wound, NSC-119875, Injury and Wounds, renal proximal tubule, p55, Physical, RNA-seq, (SP-4-2)-, Physical Traumas, MTMR15, cis Platinum, injury, proximal tubule, diamminedichloro-, Injuries and Wounds, trauma, HSN, KMIN, Wounds, traumatic injury, Wounds and Injury, Trauma, chemical analysis, (SP-4-2)-diamminedichloridoplatinum, Peyrone's chloride, KIAA1018, Whole Transcriptome Shotgun Sequencing, CDDP, Physical Trauma, Peyrone's salt, Research-Related, FAN1, cis-diammineplatinum(II) dichloride, Fan1, cis-diamminedichloroplatinum, cis-platin, cis-[PtCl2(NH3)2], AI663989, Injury, cis-diamminedichloroplatinum(II), cis-Diamminedichloroplatinum, cis-dichlorodiammineplatinum(II), cis-diamminedichloridoplatinum(II), Neoplatin, cis-DDP, SNL, Diamminodichloride, Dichlorodiammineplatinum, cis-Platinum, cis Diamminedichloroplatinum, [PtCl2(NH3)2], wound, Platinum Diamminodichloride, Platinum, cisplatine, Lederplatin, Briplatin, cisplatin, Injuries, Platamine, cisplatino, Injuries., Kidneys, proximal convoluted tubule, Traumas, Platidiam, Biocisplatinum, Cisplatin, Platino, (SP-4-2)-diamminedichloroplatinum, Research-Related Injuries, TG, cisplatinum, assay, Research-Related Injury, kidney proximal tubule, Platinex"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of proximal tubule specific Fan1 knockout transgenic kidneys subjected to cisplatin injury","description":"RNA-seq analysis of proximal tubule specific Fan1 knockout transgenic kidneys subjected to cisplatin injury","dates":{"last_updated":"2025-09-24","first_public":"2023-05-05"},"accession":"PRJNA687768","cross_references":{"GEO":["GSE163862"],"taxon":["10090"],"PubMed":["37107275"]}}