ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/093/SRR13324593/SRR13324593_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/091/SRR13324591/SRR13324591_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/095/SRR13324595/SRR13324595_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/097/SRR13324597/SRR13324597_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/095/SRR13324595/SRR13324595_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/092/SRR13324592/SRR13324592_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/097/SRR13324597/SRR13324597_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/094/SRR13324594/SRR13324594_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/092/SRR13324592/SRR13324592_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/091/SRR13324591/SRR13324591_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/090/SRR13324590/SRR13324590_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/096/SRR13324596/SRR13324596_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/094/SRR13324594/SRR13324594_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/090/SRR13324590/SRR13324590_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/093/SRR13324593/SRR13324593_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/096/SRR13324596/SRR13324596_2.fastq.gzprimaryOK200GenomicsComputational genomics, Mayo Clinichttps://www.ebi.ac.uk/ena/browser/view/PRJNA688503Mus musculusxref:PubMed:33476308We isolated liver sinusoidal endothelial cells (LSEC) from mice fed control chow (Chow) or the nonalcoholic steatohepatitis (NASH)-inducing high fat, fructose and cholesterol (FFC) diet, and subjected the cells to bulk RNA-seq. Out of 13993 transcripts detected, the adhesion molecule Vcam1 was significantly upregulated in LSEC from FFC-fed mice compared to Chow-fed mice (Log2FC: 0.925, p: 3.6x10E-18), whereas the upregulation of another adhesion molecule Icam1 (Log2FC: 0.416, p: 0.014) was not as striking as Vcam1. Overall design: Liver sinusoidial endothelial cells from NASH and control mice were subjected to bulk RNA-seq analysis.ENAfalseGenome-wide transcriptome analysis of liver sinusoidal endothelial cells in the pathogenesis of NASHGenome-wide transcriptome analysis of liver sinusoidal endothelial cells in the pathogenesis of NASH2025-09-242021-02-03PRJNA688503GSE1640061009033476308