ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/000/SRR13324600/SRR13324600_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/002/SRR13324602/SRR13324602_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/099/SRR13324599/SRR13324599_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/004/SRR13324604/SRR13324604_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/003/SRR13324603/SRR13324603_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/001/SRR13324601/SRR13324601_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/004/SRR13324604/SRR13324604_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/005/SRR13324605/SRR13324605_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/098/SRR13324598/SRR13324598_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/003/SRR13324603/SRR13324603_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/098/SRR13324598/SRR13324598_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/001/SRR13324601/SRR13324601_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/000/SRR13324600/SRR13324600_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/002/SRR13324602/SRR13324602_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/099/SRR13324599/SRR13324599_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR133/005/SRR13324605/SRR13324605_1.fastq.gzprimaryOK200GenomicsComputational genomics, Mayo Clinichttps://www.ebi.ac.uk/ena/browser/view/PRJNA688504Mus musculusWe isolated liver sinusoidal endothelial cells (LSEC) from mice fed control chow (Chow) or the nonalcoholic steatohepatitis (NASH)-inducing high fat, fructose and cholesterol (FFC) diet, and subjected the cells to Omni-ATAC-seq. Out of the top 500 differentially abundant open chromatin regions between the two groups, 498 were more robust in FFC-fed mice compared with Chow-fed mice, suggesting a genome-wide active epigenetic regulation in LSEC during NASH development. Furthermore, in combination with RNA-seq, we demonstrated a robust transcriptional upregulation of the adhesion molecule VCAM-1 in LSEC in NASH pathogenesis. Overall design: Liver sinusodial endothelial cells from NASH and control mice were subjected to Omni-ATAC-seq analysis.xref:PubMed:33476308ENAfalseGenome-wide open chromatin analysis of liver sinusoidal endothelial cells in the pathogenesis of NASHGenome-wide open chromatin analysis of liver sinusoidal endothelial cells in the pathogenesis of NASH2025-09-242021-02-03PRJNA688504GSE1640081009033476308