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Hospital of Philadelphia"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA689595"],"long_description":["Human dental caries is an intractable biofilm-associated disease caused by microbial interactions on the host's teeth. Commensal bacteria help control opportunistic pathogens via bioactive products such as hydrogen peroxide (H2O2). However, high-sugar consumption disrupts homeostasis and promotes pathogen accumulation in acidic biofilms that cause tooth-decay. Here, we exploit the pathological (sugar-rich/acidic) conditions using a nanohybrid system to increase intrinsic H2O2 production and trigger reactive oxygen species (ROS) for efficient biofilm virulence targeting. The nanohybrid contains glucose-oxidase that catalyzes glucose present in biofilms to increase intrinsic H2O2, which is converted by iron oxide nanoparticles with peroxidase-like activity into ROS in acidic pH. Notably, it selectively kills Streptococcus mutans (pathogen) without affecting Streptococcus oralis (commensal) via preferential pathogen-binding and in situ ROS generation. Furthermore, nanohybrid treatments potently reduced dental caries in a rodent model. Compared to chlorhexidine (positive-control), which disrupted oral microbiota diversity, the nanohybrid had significant higher efficacy without affecting soft-tissues and the gastrointestinal microbiomes, while modulating dental health-associated microbial activity in vivo. The data reveal therapeutic precision of a bi-functional hybrid nanozyme against a biofilm-related disease in a controlled-manner activated by pathological conditions."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Precision targeting of bacterial pathogen via bi-functional nanozyme activated by biofilm microenvironment","dates":{"last_updated":"2023-05-19","first_public":"2021-01-06"},"accession":"PRJNA689595","cross_references":{}}