{"database":"ENA","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Fastqsanger.gz":["ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/025/SRR13443725/SRR13443725_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/024/SRR13443724/SRR13443724_2.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/024/SRR13443724/SRR13443724_1.fastq.gz","ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/025/SRR13443725/SRR13443725_2.fastq.gz"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["Life Sciences, Nanjing University"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA692434"],"scientific_name":["Mus musculus"],"long_description":["Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and microsatellite stable (MSS) phenotypes. Although SHP2 is a potential target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing was performed to explore the role of SHP2 in all cell types of tumor microenvironment (TME) from murine MC38 xenografts. Overall design: SHP2i-remodeled TME revealed by scRNA-seq"],"tag":["xref:PubMed:35127377"],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomics analysis of the tumor microenvironment from murine MC38 xenografts upon SHP099 treatment","description":"Single-cell transcriptomics analysis of the tumor microenvironment from murine MC38 xenografts upon SHP099 treatment","dates":{"last_updated":"2025-09-24","first_public":"2022-01-03"},"accession":"PRJNA692434","cross_references":{"GEO":["GSE164908"],"taxon":["10090"],"PubMed":["35127377"]}}