ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/025/SRR13443725/SRR13443725_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/024/SRR13443724/SRR13443724_2.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/024/SRR13443724/SRR13443724_1.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR134/025/SRR13443725/SRR13443725_2.fastq.gzprimary200OKGenomicsLife Sciences, Nanjing Universityhttps://www.ebi.ac.uk/ena/browser/view/PRJNA692434Mus musculusColorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and microsatellite stable (MSS) phenotypes. Although SHP2 is a potential target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing was performed to explore the role of SHP2 in all cell types of tumor microenvironment (TME) from murine MC38 xenografts. Overall design: SHP2i-remodeled TME revealed by scRNA-seqxref:PubMed:35127377ENAfalseSingle-cell transcriptomics analysis of the tumor microenvironment from murine MC38 xenografts upon SHP099 treatmentSingle-cell transcriptomics analysis of the tumor microenvironment from murine MC38 xenografts upon SHP099 treatment2025-09-242022-01-03PRJNA692434GSE1649081009035127377