ENAapplication/xmlftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/092/SRR13757792/SRR13757792.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/086/SRR13757786/SRR13757786.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/095/SRR13757795/SRR13757795.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/097/SRR13757797/SRR13757797.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/084/SRR13757784/SRR13757784.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/094/SRR13757794/SRR13757794.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/083/SRR13757783/SRR13757783.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/090/SRR13757790/SRR13757790.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/088/SRR13757788/SRR13757788.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/081/SRR13757781/SRR13757781.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/096/SRR13757796/SRR13757796.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/082/SRR13757782/SRR13757782.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/085/SRR13757785/SRR13757785.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/087/SRR13757787/SRR13757787.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/093/SRR13757793/SRR13757793.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/091/SRR13757791/SRR13757791.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/089/SRR13757789/SRR13757789.fastq.gzftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR137/080/SRR13757780/SRR13757780.fastq.gzprimaryOK200GenomicsArthur Weiss, Department of Medicine, University of California, San Franciscohttps://www.ebi.ac.uk/ena/browser/view/PRJNA703544Mus musculusWe found that gene signatures characteristic of unresponsive cells were strongly enriched in peripheral W131AOTII CD4 T cells but not in CD4 single positive (CD4SP) thymocytes. Furthermore, loss of Cbl-b in W131AOTII mice significantly altered gene expression profile associated with improved T cell responsiveness. Overall design: RNA sequencing of T cells isolated from OTII, Cbl-b-/-OTII, W131AOTII and Cbl-b-/-W131AOTII to investigate the possible downstream signaling pathways that cbl-b controls and rescues T cell responsiveness in T cell anergy.xref:PubMed:33974042ENAfalseRNA sequencing of T cells in the genetically encoded mouse model of T cell anergy (W131AOTII)RNA sequencing of T cells in the genetically encoded mouse model of T cell anergy (W131AOTII)2025-09-242021-02-23PRJNA703544GSE1671691009033974042