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We observed strikingly increased expression levels of CCL2 as well as macrophage infiltration in heart tissues of COVID-19 patients. We generated an immuno-cardiac co-culture platform containing human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) and macrophages. We found that macrophages induce increased reactive oxygen species (ROS) and apoptosis in CMs by secreting IL-6 and TNF-α after SARS-CoV-2 exposure. Using this immuno-cardiac co-culture platform, we performed a high content screen and identified ranolazine and tofacitinib as compounds that protect CMs from macrophage-induced cardiotoxicity. We established an immuno-host co-culture system to study macrophage-induced host cell damage following SARS-CoV-2 infection, and identified FDA-approved drug candidates that alleviate the macrophage-mediated hyper-inflammation and cellular injury. Overall design: 23 total samples. At least three samples' replicates were done for each group."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"hPSC-derived cells to model Macrophage-mediated inflammation in COVID19 Hearts","description":"hPSC-derived cells to model Macrophage-mediated inflammation in COVID19 Hearts","dates":{"last_updated":"2025-09-24","first_public":"2021-04-18"},"accession":"PRJNA715767","cross_references":{"GEO":["GSE169241"],"taxon":["9606"],"PubMed":["33853355"]}}