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Weill Cornell Medical College</center_name><full_dataset_link>https://www.ebi.ac.uk/ena/browser/view/PRJNA715767</full_dataset_link><scientific_name>Homo sapiens</scientific_name><tag>xref:PubMed:33853355</tag><long_description>We systematically compared autopsy samples from non-COVID-19 donors and COVID-19 patients using RNA-seq and immunohistochemistry. We observed strikingly increased expression levels of CCL2 as well as macrophage infiltration in heart tissues of COVID-19 patients. We generated an immuno-cardiac co-culture platform containing human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) and macrophages. We found that macrophages induce increased reactive oxygen species (ROS) and apoptosis in CMs by secreting IL-6 and TNF-α after SARS-CoV-2 exposure. Using this immuno-cardiac co-culture platform, we performed a high content screen and identified ranolazine and tofacitinib as compounds that protect CMs from macrophage-induced cardiotoxicity. We established an immuno-host co-culture system to study macrophage-induced host cell damage following SARS-CoV-2 infection, and identified FDA-approved drug candidates that alleviate the macrophage-mediated hyper-inflammation and cellular injury. Overall design: 23 total samples. At least three samples' replicates were done for each group.</long_description><repository>ENA</repository></additional><is_claimable>false</is_claimable><name>hPSC-derived cells to model Macrophage-mediated inflammation in COVID19 Hearts</name><description>hPSC-derived cells to model Macrophage-mediated inflammation in COVID19 Hearts</description><dates><last_updated>2025-09-24</last_updated><first_public>2021-04-18</first_public></dates><accession>PRJNA715767</accession><cross_references><GEO>GSE169241</GEO><taxon>9606</taxon><PubMed>33853355</PubMed></cross_references></HashMap>