{"database":"ENA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"center_name":["University of Oxford"],"full_dataset_link":["https://www.ebi.ac.uk/ena/browser/view/PRJNA725410"],"long_description":["miRNA expression is altered in virtually all human cancers. Proteins in the MAP kinase pathway may mediate changes miRNA biogenesis and Ago2 activity in cancer cells (Treiber, Treiber, &amp Meister, 2019). Grb2 has been shown to enhance EGFR-mediated regulation of miRNA-loading onto Ago2 (Shen et al., 2013). Additionally, it has been suggested that Grb2 may associate with Ago2 (Haidar et al., 2018). In this study, we investigated a direct role for Grb2 in the regulation of miRNA-loading onto Ago2. The potential interaction between Grb2 and Ago2 was examined. Small-RNA sequencing of cells depleted of Grb2 was used to identify a miRNA expression signature which was dependent on Grb2. The mechanism by which Grb2 mediated changes in miRNA expression was explored and the relevance of this mechanism in cancer was considered. Therefore, this work may indicate new avenues for cancer therapy."],"repository":["ENA"],"additional_accession":[]},"is_claimable":false,"name":"","description":"Grb2 regulation of miRNA expression","dates":{"last_updated":"2024-07-19","first_public":"2024-05-11"},"accession":"PRJNA725410","cross_references":{}}